SYDE1 Activators
Compounds such as Rhosin, Y-27632, NSC23766, and ML141, which target Rho GTPases and their downstream effectors, can modulate cytoskeletal dynamics and cell migration, processes in which SYDE1 is likely involved. By altering the activity of key molecules in these pathways, these compounds might indirectly enhance the functional role of SYDE1 in cellular reorganization and movement.
Further, LY294002 and PD98059, targeting the PI3K/Akt and MAPK/ERK pathways respectively, could influence SYDE1's function in cell survival and proliferation. Forskolin, by increasing cAMP levels, might also affect SYDE1-mediated signaling pathways, especially those related to cell motility. Wiskostatin, CK-666, and Jasplakinolide, by modulating the dynamics of the actin cytoskeleton, could affect SYDE1's role in actin filament organization and cell shape. Moreover, Blebbistatin and ML7, which inhibit myosin II and MLCK, could impact processes of cell motility and contraction where SYDE1 might be functionally active.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, impacting Rho-associated protein kinase, which is downstream of Rho GTPases, potentially affecting SYDE1's function in cytoskeletal dynamics. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, could influence PI3K/Akt signaling pathways, potentially affecting SYDE1's role in cell survival and migration. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MAPK/ERK pathway inhibitor, which could indirectly impact SYDE1's function in cellular responses related to this pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Enhances cAMP levels, potentially influencing SYDE1-mediated signaling pathways, particularly in processes related to cell motility. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Inhibits N-WASP, impacting actin polymerization regulation, potentially affecting SYDE1's role in actin cytoskeleton reorganization. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
Inhibits the Arp2/3 complex, potentially influencing SYDE1's involvement in actin filament branching and cell movement. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments, potentially impacting SYDE1's function in actin dynamics and cell shape regulation. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II, affecting cell motility processes where SYDE1 might play a role, particularly in myosin-driven cell movement. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), potentially affecting SYDE1's involvement in cellular processes driven by actomyosin contraction. | ||||||