Swi3 Inhibitors
SWI3 inhibitors represent a class of chemical compounds designed to specifically target the SWI3 protein, a critical component of the SWI/SNF chromatin remodeling complex. This class of inhibitors plays a crucial role in the realm of molecular biology and cellular research by offering tools to investigate the intricacies of chromatin remodeling and gene regulation processes. SWI/SNF complexes are involved in the dynamic restructuring of chromatin, which regulates gene expression and cell fate determination. SWI3, as a central subunit of these complexes, orchestrates the ATP-dependent chromatin remodeling activity that influences the accessibility of DNA to transcription factors and RNA polymerases.
SWI3 inhibitors are developed to interfere with SWI3's function, typically by disrupting its interactions with other subunits within the SWI/SNF complex or its binding to critical co-factors. By inhibiting SWI3, these compounds provide researchers with valuable insights into the mechanistic details of chromatin remodeling processes. They serve as essential tools for deciphering how changes in chromatin structure influence gene expression patterns, which, in turn, impact cellular functions and development. SWI3 inhibitors, alongside other chemical probes, enable scientists to investigate the role of SWI/SNF complexes in various cellular processes, such as differentiation, DNA repair, and cellular response to environmental cues. Their precise targeting of SWI3 offers a powerful means to dissect the complexities of chromatin dynamics and better understand the fundamental principles governing gene regulation in both normal and pathological cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A-485 is a small molecule inhibitor that targets the SWI3 protein by blocking its interaction with other proteins involved in chromatin remodeling. It disrupts the formation of SWI/SNF complexes, leading to inhibition of gene expression and cell growth in cancer cells. | ||||||
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
PFI-3 is a chemical compound that inhibits SWI3 by binding to its active site. It disrupts the ATP-dependent chromatin remodeling activity of SWI/SNF complexes, leading to gene expression changes and anti-cancer effects. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a SWI3 inhibitor that disrupts the interaction between SWI3 and its coactivator CBP/p300. This interference inhibits the acetylation of histones and gene transcription, making it a potential anti-cancer agent. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule inhibitor that indirectly targets SWI3 by inhibiting BRD4, a protein involved in chromatin remodeling. By blocking BRD4, JQ1 can alter gene expression in cancer cells. | ||||||
BI 9564 | 1883429-22-8 | sc-507350 | 1 mg | $83.00 | ||
BI-9564 is a SWI3 inhibitor that disrupts the assembly of SWI/SNF complexes. It interferes with the interaction between SWI3 and other subunits, leading to impaired chromatin remodeling and gene expression. | ||||||
PRT4165 | 31083-55-3 | sc-507487 | 10 mg | $134.00 | ||
PRT4165 is a chemical compound that inhibits SWI3 by interfering with the assembly of SWI/SNF complexes. It disrupts the binding of SWI3 to ATP, leading to impaired chromatin remodeling and gene regulation. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is an inhibitor of SWI3-containing complexes, specifically targeting the SNF5 subunit. It disrupts the ATPase activity of SWI/SNF complexes, impairing their chromatin remodeling function. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
SD-208 inhibits SWI3 by targeting the TGF-β type I receptor, which is involved in signaling pathways that regulate SWI3 activity. By blocking this pathway, SD-208 affects gene expression in cancer cells. | ||||||