Date published: 2026-1-12

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SURF-6 Activators

Retinoic acid serves as a potent modulator of gene expression, shaping the nucleolar architecture and, by extension, potentially enhancing the functional dynamics of SURF-6. Compounds such as Rolipram elevate intracellular cAMP levels, triggering a cascade of signaling events that can recalibrate nuclear activities, including those associated with SURF-6. The incorporation of polyamines like spermidine into cellular processes is known to stabilize nucleic acid structures, aiding in ribosome assembly and thus potentially facilitating the role of SURF-6 in this intricate process.

Furthermore, certain nucleic acid-binding antibiotics, like actinomycin D and Mithramycin A, bind directly to DNA or interfere with RNA synthesis, thereby exerting a profound effect on nucleolar integrity and function, which could consequentially alter SURF-6 activity. Inhibitors such as rapamycin and leptomycin B target pivotal components of the protein synthesis machinery, influencing the mTOR pathways and nuclear export, respectively, and thereby indirectly affecting SURF-6 function. The disruption of ribosomal RNA synthesis by compounds like CX-5461 or the induction of nucleolar stress by agents such as BMH-21 and toyocamycin can lead to changes in the nucleolar landscape that may influence SURF-6. Moreover, mycophenolic acid's inhibition of inosine monophosphate dehydrogenase has repercussions for nucleotide biosynthesis and ribosome assembly, which are fundamental to the functional engagement of SURF-6.

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Items 11 to 12 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Toyocamycin

606-58-6sc-362812
10 mg
$138.00
(1)

Toyocamycin is an adenosine analog that can induce nucleolar stress and potentially affect SURF-6 function.

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$69.00
$266.00
8
(1)

Mycophenolic acid inhibits inosine monophosphate dehydrogenase, potentially affecting ribosome biogenesis and SURF-6 activity.