Date published: 2025-9-11

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SUN3激活剂

SUN3 activators pertain to a category of chemical agents that modulate the activity of a specific subset of proteins or cellular mechanisms identified as 'SUN3.' The 'SUN' in their name often denotes a specific characteristic or functional domain within the proteins they target, which could be an acronym found in a more technical, scientific nomenclature. These activators are designed to interact precisely with their target sites, initiating a cascade of biochemical interactions. The chemical structure of SUN3 activators typically features molecular moieties that enable them to engage with the active or allosteric sites of SUN3 proteins. This engagement is achieved through non-covalent interactions such as hydrogen bonding, van der Waals forces, and hydrophobic effects, which contribute to the specificity and selectivity of these activators toward their intended targets.

The development and investigation of SUN3 activators involve a rigorous process of chemical synthesis, characterization, and analysis. Researchers utilize various techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry to elucidate the structural details of these compounds. Such detailed structural information is crucial for understanding the mechanism of action at the molecular level. The molecular framework of SUN3 activators is often optimized through iterative processes of structure-activity relationship (SAR) studies, allowing chemists to refine the efficacy and specificity of these compounds. The physical properties of SUN3 activators, such as solubility, stability, and permeability, are also fine-tuned to ensure that they can effectively reach and interact with their target sites within a given context. Through these comprehensive studies, the precise function and role of SUN3 within the biochemical pathways can be better understood, paving the way for advanced research into the modulation of these specific proteins or processes.

関連項目

Items 1 to 10 of 11 total

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产品名称CAS #产品编号数量价格应用排名

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

佛司可林直接激活腺苷酸环化酶,导致环状AMP(cAMP)水平升高。cAMP升高可激活蛋白激酶A(PKA),后者可磷酸化多种蛋白质,可能包括SUN3,从而增强其在细胞内的功能活性。

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA是一种二酰基甘油类似物,可激活蛋白激酶C(PKC)。PKC激活可导致下游磷酸化反应,其中可能包括SUN3的磷酸化反应和随后的激活。

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

离子霉素是一种钙离子载体,可提高细胞内钙离子水平,从而激活钙离子依赖性信号通路。钙的涌入可通过调节SUN3与钙敏感伴侣蛋白的结合来影响其功能活性。

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG是一种绿茶中的多酚,具有抑制激酶活性的作用。通过抑制某些激酶,EGCG可以减少竞争性磷酸化,从而增加SUN3受其特定激酶的磷酸化与活化。

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002是一种PI3K抑制剂,可改变PI3K/Akt途径。该途径的下调可能会导致其他信号传导途径的补偿性增加,包括SUN3的激活。

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

S1P是一种生物活性脂质,可激活鞘氨醇-1-磷酸受体,从而引发包括细胞骨架重组在内的多种信号级联反应,并可能激活SUN3的功能。

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin 是一种 SERCA 泵抑制剂,可导致细胞膜钙水平升高。这会激活钙依赖性信号机制,从而增强 SUN3 的活性。

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine是一种广谱激酶抑制剂,但可通过抑制过度活跃的激酶来选择性激活信号通路,从而可能提高SUN3的活性。

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 是一种钙离子拮抗剂,能提高细胞内的钙水平,从而可能通过钙依赖途径增强 SUN3 的功能。

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

冈田酸是蛋白磷酸酶PP1和PP2A的强效抑制剂,可增加细胞内的磷酸化水平,从而提高SUN3的活性(如果SUN3受磷酸化调节的话)。