SULT2A5 Inhibitors
Chemical inhibitors of SULT2A5 include a variety of compounds predominantly found in natural sources, such as plants. These inhibitors, including flavonoids like Quercetin, Chrysin, Kaempferol, Myricetin, and Apigenin, polyphenols such as Chlorogenic acid and Ellagic acid, the stilbenoid Resveratrol, and the isoflavone Genistein, can impede the enzymatic activity of SULT2A5 through several mechanisms. Quercetin and Chrysin, for instance, can bind to the active site of SULT2A5, which is the region where the enzyme's normal substrates would bind. By occupying this space, these compounds prevent the enzyme from catalyzing the sulfonation reaction, a process whereby the enzyme transfers a sulfo group to its substrates. Similarly, Kaempferol and Myricetin can inhibit the activity of SULT2A5 by competing with physiological substrates for access to the active site, effectively blocking the reaction pathway.
Other chemical inhibitors like Chlorogenic acid and Ellagic acid may alter the conformation of SULT2A5, which can disrupt the enzyme's ability to function properly. Resveratrol operates by a similar competitive mechanism, docking at the enzyme's active site and thus preventing substrate binding. Genistein can also bind to this crucial functional domain of SULT2A5, inhibiting the sulfonation of the enzyme's substrates. In the same vein, Curcumin is believed to bind to the active site, which would impede the enzyme's normal functioning. The compound 3,3'-Diindolylmethane can interfere with SULT2A5's activity by inhibiting the transfer of the sulfo group, although the exact mechanism may vary from the direct active site competition seen with other inhibitors. Lastly, Epigallocatechin gallate (EGCG) demonstrates an inhibitory effect by directly binding to SULT2A5, which could interfere with its sulfonation activity, demonstrating a broad spectrum of interactions that different chemical structures can have with this sulfotransferase enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
As a flavonoid, Quercetin can inhibit sulfotransferase activity, and thus, it can inhibit the sulfoconjugation function of SULT2A5 by competing with the sulfuryl donor substrate, which is pivotal for the protein's enzymatic activity. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $47.00 $69.00 | 1 | |
Chlorogenic acid, as a polyphenol, has been shown to inhibit sulfotransferases. It may inhibit SULT2A5 by binding to the active site or altering the enzyme's conformation, thereby preventing the transfer of the sulfo group from the donor to acceptors. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
This compound, a derivative of indole-3-carbinol from cruciferous vegetables, can inhibit sulfotransferase enzymes, thus it can inhibit SULT2A5 by interfering with the enzyme's sulfuryl transfer activity. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavone that can inhibit various sulfotransferases. It can inhibit SULT2A5 by competing with the physiological substrates for the active site, which can block the sulfonation reaction catalyzed by the enzyme. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit sulfotransferase enzymes, which suggests it can inhibit SULT2A5 by binding to its active site and preventing the enzyme from catalyzing the sulfonation of its substrates. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As a stilbenoid, Resveratrol can inhibit the function of sulfotransferases, including SULT2A5, by competing with the natural substrates for binding to the active site, thus inhibiting the sulfonation reaction. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid, a polyphenol, can inhibit the sulfonation activity of sulfotransferases. It can inhibit SULT2A5 by blocking the active site or altering the protein structure, thereby inhibiting its enzymatic activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the major catechin in green tea, can inhibit SULT2A5 activity by directly binding to the enzyme and interfering with its normal function of sulfonation of substrates. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can inhibit sulfotransferase activity. It can functionally inhibit SULT2A5 by occupying the active site, thus preventing the transfer of sulfuryl groups to the enzyme's substrates. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is a flavonol known to inhibit sulfotransferases. It can inhibit SULT2A5 by binding to the enzyme's active site, obstructing the access of substrates necessary for the sulfonation process. | ||||||