STRAP Inhibitors
STRAP inhibitors belong to a distinctive chemical class that plays a pivotal role in regulating cellular processes, particularly those associated with cellular signaling and protein interactions. The term "STRAP" itself stands for 'serine-threonine kinase receptor-associated protein,' highlighting the essential role this class of inhibitors plays in modulating the activity of serine-threonine kinases. Serine-threonine kinases are enzymes crucial for intracellular signal transduction, and STRAP inhibitors exert their influence by specifically targeting and binding to the STRAP protein, disrupting its normal function.
The inhibition of STRAP, facilitated by these compounds, can have profound implications for various cellular pathways. STRAP is known to interact with TGF-β (transforming growth factor-beta) receptors, affecting the TGF-β signaling pathway, which is pivotal in cellular development, differentiation, and homeostasis. By impeding the interaction between STRAP and its molecular partners, STRAP inhibitors exhibit the potential to modulate TGF-β signaling cascades and downstream cellular responses. This unique mechanism of action underscores the significance of STRAP inhibitors as a promising class of compounds for further exploration in understanding and potentially manipulating cellular processes at the molecular level.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that can inhibit a wide range of kinases which may include kinases interacting with STRAP. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that could affect signaling pathways involving STRAP through indirect modulation of the AKT signaling cascade. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor which might alter STRAP-related signaling by affecting c-Jun N-terminal kinase activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that could modify STRAP-related signaling pathways involved in stress response. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that could indirectly impact STRAP function by modulating cell growth and proliferation signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that can alter pathways associated with STRAP by inhibiting the phosphoinositide 3-kinases family. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
A multi-kinase inhibitor that might affect STRAP-associated pathways by targeting RAF kinases and others. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
A Src kinase inhibitor which may indirectly influence STRAP function by modulating Src family kinase-mediated signaling. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
A tyrosine kinase inhibitor that might affect STRAP through its action on BCR-ABL and other kinases. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
An Src family kinase inhibitor, which can affect STRAP signaling pathways through the inhibition of Src kinases. | ||||||