Stim2 Inhibitors
Inhibitors classified as STIM2 Inhibitors comprise various compounds that indirectly suppress the activation of STIM2. These inhibitors operate through a range of mechanisms, all of which converge on maintaining sufficient calcium levels within the ER to prevent the activation of STIM2. By doing so, they inhibit the normal function of STIM2, which is to sense the depletion of calcium within the ER and subsequently activate SOC channels to replenish calcium levels. These inhibitors can affect STIM2 function by preventing the conformational changes required for its activation, blocking the interaction between STIM2 and SOCs, or altering the calcium handling properties of the ER to obviate the need for STIM2 activation.
The impact of these inhibitors on cellular calcium dynamics is significant since STIM2-mediated calcium signaling plays a critical role in numerous physiological processes. By inhibiting STIM2, these compounds can attenuate the calcium influx that follows ER calcium store depletion, thus providing a means to explore the cellular functions of STIM2 and its role in SOCE.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
Originally identified as an inhibitor of SOC channels, it may also prevent the activation of STIM2 by stabilizing ER calcium levels. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Although it modulates calcium channels, at certain concentrations it can inhibit the interaction between STIM2 and SOCs. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
Inhibits receptor-mediated calcium entry, which may also prevent STIM2 activation due to maintained ER calcium levels. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
While it inhibits myosin light-chain kinase, it can also affect calcium dynamics, potentially inhibiting STIM2 activity. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
An IP3 receptor inhibitor that may stabilize ER calcium concentration, indirectly inhibiting STIM2 activation. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $89.00 | ||
A lanthanide ion that blocks various calcium channels, potentially affecting the activation of STIM2. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
Can interfere with intracellular calcium release and may lead to the inhibition of STIM2 by preventing calcium depletion in the ER. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
An inhibitor of calcium uptake that could stabilize ER calcium levels, thereby inhibiting STIM2. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Known for its antifungal properties, it can also inhibit calcium signaling pathways, potentially affecting STIM2 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Primarily a calcium channel blocker, which might indirectly prevent STIM2 activation by modulating intracellular calcium levels. | ||||||