stefin A3 Activators
Stefin A3 Activators are a class of chemicals that enhance the functional activity of stefin A3 via distinct pathways. Dexamethasone, a glucocorticoid receptor agonist, enhances stefin A3 activity by triggering nuclear translocation of the glucocorticoid receptor. Salicylate and acetylsalicylic acid (aspirin) inhibit NF-kappaB and cyclooxygenase (COX) enzymes respectively, thus reducing protease expression and inflammatory responses rich in proteases, both actions indirectly enhancing stefin A3 activity. Similarly, indomethacin enhances stefin A3 function by reducing protease-rich inflammatory responses.
Suramin inhibits the binding of growth factors to their receptors, reducing protease-rich growth factor signaling and thus indirectly enhancing stefin A3 activity. Amiloride enhances stefin A3 function by reducing plasminogen activation and subsequent protease activity. E-64, leupeptin, and pepstatin A are protease inhibitors that reduce competition with stefin A3, thus enhancing its function. Aprotinin and EDTA, a metal ion chelating agent, enhance stefin A3 activity by reducing serine protease and metalloprotease activities respectively. Tranexamic Acid enhances stefin A3 function by reducing plasmin activity and subsequent protease activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Upon binding, it triggers the nuclear translocation of the glucocorticoid receptor, which can enhance the transcription of genes including those involved in protease inhibition. This action can indirectly enhance the functional activity of stefin A3, a known cysteine protease inhibitor. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate inhibits NF-kappaB signaling. This action can reduce the expression of proteases, thus indirectly enhancing the functional activity of stefin A3 by reducing the competition for its inhibitory effects. | ||||||
5-Acetylsalicylic acid | 13110-96-8 | sc-267900 | 5 g | $135.00 | ||
Acetylsalicylic Acid, also known as aspirin, inhibits cyclooxygenase (COX) enzymes. This leads to a decrease in pro-inflammatory prostaglandins, which can indirectly enhance the functional activity of stefin A3 by reducing protease-rich inflammatory responses. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX enzymes. This leads to reduced synthesis of prostaglandins and other pro-inflammatory mediators, which can indirectly enhance the functional activity of stefin A3 by reducing protease-rich inflammatory responses. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a polysulfonated napthylamine that inhibits the binding of growth factors to their receptors. This action can indirectly enhance the functional activity of stefin A3 by reducing protease-rich growth factor signaling. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is a sodium channel inhibitor that also inhibits the urokinase-type plasminogen activator (uPA). Inhibition of uPA can indirectly enhance the functional activity of stefin A3 by reducing plasminogen activation and subsequent protease activity. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 is a potent and irreversible inhibitor of cysteine proteases. This can enhance the functional activity of stefin A3 by reducing the competition for its inhibitory effects. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is a potent inhibitor of serine and cysteine proteases. This can enhance the functional activity of stefin A3 by reducing the competition for its inhibitory effects. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Aprotinin is a serine protease inhibitor that can indirectly enhance the functional activity of stefin A3 by reducing serine protease activity, thereby reducing the competition for stefin A3's inhibitory effects. | ||||||
Tranexamic acid | 1197-18-8 | sc-204921 sc-204921A | 5 g 10 g | $29.00 $50.00 | 10 | |
Tranexamic Acid is a plasminogen activation inhibitor that can indirectly enhance the functional activity of stefin A3 by reducing plasmin activity and subsequent protease activity. | ||||||