STAM2 Inhibitors

STAM2 inhibitors target and inhibit Signal Transducing Adaptor Molecule 2 (STAM2), a protein implicated in intracellular signaling and trafficking pathways. STAM2 is a part of the endosomal sorting complex required for transport (ESCRT) system, playing a pivotal role in the sorting of ubiquitinated cargo proteins for lysosomal degradation. The function of STAM2 in cellular processes, particularly in the regulation of receptor signaling and degradation, makes it a notable target for specific inhibitors. These inhibitors often incorporate functional groups and structural motifs that engage with key regions of STAM2, such as its SH3 domain or ubiquitin-interacting motifs. These inhibitors have complex molecular frameworks that can mimic or compete with the natural substrates or binding partners of STAM2, thereby inhibiting its function.