SRp75 Inhibitors

SRp75 inhibitors belong to a class of small molecules designed to modulate the activity of SRp75, a crucial component of the splicing machinery in eukaryotic cells. SRp75, also known as serine and arginine-rich splicing factor 4 (SRSF4), is a member of the serine/arginine-rich (SR) protein family that plays a pivotal role in pre-mRNA splicing. Pre-mRNA splicing is a fundamental cellular process that ensures the removal of introns and the proper joining of exons to generate mature mRNA transcripts. This process is essential for the synthesis of functional proteins in eukaryotic organisms. SRp75 is involved in both constitutive and alternative splicing, making it a critical factor in regulating gene expression and ultimately influencing cellular functions.

SRp75 inhibitors are designed to selectively bind to SRp75 and modulate its activity. By doing so, these inhibitors can alter the splicing patterns of specific genes, leading to changes in the protein isoforms produced by those genes. This modulation of splicing can have far-reaching consequences for cellular function and gene expression. Researchers have been exploring SRp75 inhibitors as valuable tools for studying the intricacies of splicing regulation in cells and as agents for manipulating gene expression in various contexts.