SRp75 Inhibitors
SRp75 inhibitors belong to a class of small molecules designed to modulate the activity of SRp75, a crucial component of the splicing machinery in eukaryotic cells. SRp75, also known as serine and arginine-rich splicing factor 4 (SRSF4), is a member of the serine/arginine-rich (SR) protein family that plays a pivotal role in pre-mRNA splicing. Pre-mRNA splicing is a fundamental cellular process that ensures the removal of introns and the proper joining of exons to generate mature mRNA transcripts. This process is essential for the synthesis of functional proteins in eukaryotic organisms. SRp75 is involved in both constitutive and alternative splicing, making it a critical factor in regulating gene expression and ultimately influencing cellular functions.
SRp75 inhibitors are designed to selectively bind to SRp75 and modulate its activity. By doing so, these inhibitors can alter the splicing patterns of specific genes, leading to changes in the protein isoforms produced by those genes. This modulation of splicing can have far-reaching consequences for cellular function and gene expression. Researchers have been exploring SRp75 inhibitors as valuable tools for studying the intricacies of splicing regulation in cells and as agents for manipulating gene expression in various contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As an HDAC inhibitor, Trichostatin A could alter chromatin structure, potentially impacting the transcription and expression of SRSF4. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
This kinase inhibitor might influence the phosphorylation state of SRSF4 or its interacting partners, indirectly affecting its activity. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
By targeting the spliceosome, Pladienolide B could indirectly impact the function of splicing factors like SRSF4. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can alter gene expression patterns, which could influence SRSF4 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY294002 could impact various signaling pathways, potentially influencing the activity or expression of SRSF4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
This MEK inhibitor can affect the MAPK/ERK pathway, which might have downstream effects on the expression or activity of splicing factors. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, Rapamycin can influence cellular processes and gene expression, potentially impacting SRSF4. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
This compound causes DNA damage and cellular stress, which could influence the expression or activity of splicing factors. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
As a JNK inhibitor, SP600125 might influence signaling pathways that regulate the activity or expression of SRSF4. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
This proteasome inhibitor can influence protein degradation pathways, potentially impacting the stability of SRSF4. | ||||||