SRp75 activators encompass a class of molecules that are known for their ability to enhance the activity or expression of SRp75. SRp75, a part of the serine/arginine-rich (SR) protein family, is integral to the process of splicing - a fundamental part of gene expression where introns are removed from pre-mRNA transcripts and exons are connected to create the mature mRNA. SRp75, and SR proteins in general, have roles in both constitutive and alternative splicing, the latter of which enables the generation of diverse protein products from a single gene. Thus, activators of SRp75 exert influence on this critical aspect of gene expression.
SRp75 activators can operate through a variety of mechanisms. Some may interact directly with SRp75, enhancing its ability to participate in the splicing process. Others may influence the expression of SRp75 by impacting the transcription or translation of the SRp75 gene, thereby increasing the cellular level of SRp75. There are also compounds that might affect upstream or downstream signaling pathways that indirectly modulate SRp75 activity. For instance, some SRp75 activators might influence how cells respond to stress or damage, which could, in turn, have a bearing on the role of SRp75 in these responses. Despite the differences in their specific mechanisms of action, all SRp75 activators share the common characteristic of enhancing the activity or expression of SRp75 in one way or another. These compounds provide an invaluable toolset for studying the complex process of splicing and the crucial role of SRp75 within it.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole might induce SRp75 expression as part of its broad effects on cellular microtubule dynamics. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen might influence SRp75 expression due to its selective estrogen receptor modulatory properties. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin might modulate SRp75 expression due to its interactions with endoplasmic reticulum stress response. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine might influence SRp75 expression through its effects on DNA hypomethylation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin could potentially upregulate SRp75 due to its action on topoisomerase I inhibition. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C could potentially induce SRp75 expression as part of its effects on DNA crosslinking. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin could potentially induce SRp75 expression due to its potent effects on heat shock protein 90 (Hsp90). | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid might enhance SRp75 expression via its histone deacetylase (HDAC) inhibitory properties. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid could potentially induce SRp75 expression due to its effects on HDAC inhibition and GABAergic signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could potentially upregulate SRp75 through its role in cellular antioxidant response. | ||||||