SRP68 Activators

SRP68 activators are a category of chemicals that indirectly influence the activity of the SRP68 protein. These compounds primarily act by modulating protein synthesis, a process intricately linked to SRP68 function. By manipulating the protein synthesis machinery, these chemicals can indirectly affect the role of SRP68 in the translocation of proteins across the endoplasmic reticulum membrane. Within this class, there are inhibitors of protein synthesis. For instance, activators disrupt protein synthesis by blocking the translocation step, which is a crucial phase where SRP68 is actively involved. Similarly,activators of this class obstruct elongation at the ribosome level, which can indirectly influence the SRP68 pathway.

Additionally, the group includes mTOR inhibitors. The mTOR pathway is a central regulator of cell growth and protein synthesis. For instance, activators can indirectly influence SRP68 functionality by modulating the protein synthesis machinery. Similarly, activators also form a complex with FKBP12 to inhibit mTOR, a protein kinase that plays a pivotal role in protein synthesis and cell proliferation.