SRP68 Antibody (4-YD13): sc-135569

SRP68 Antibody (4-YD13) is a mouse monoclonal IgG2a kappa light chain antibody that detects SRP68 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SRP68 antibody (4-YD13) is available as the non-conjugated format. The signal recognition particle (SRP) plays a crucial role in the cellular process of targeting and translocating proteins to the endoplasmic reticulum (ER), which is essential for the proper processing of membrane and secreted proteins. SRP is a ribonucleoprotein complex composed of a unique Alu domain and an S domain that includes six proteins, among which SRP68 is a key component. SRP68 interacts with SRP RNA, enhancing the binding of SRP72, and is involved in the assembly of the SRP complex. SRP68 localization in both the nucleolus and cytoplasm highlights a dual role in the assembly of ribonucleoproteins and in the cytoplasmic processes of protein synthesis. SRP68 accumulates in the ER, indicating importance in the final stages of protein maturation and transport. Understanding SRP68 function and interactions is vital for elucidating the mechanisms of protein targeting and translocation, which are fundamental to cellular function and homeostasis.

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SRP68 Antibody (4-YD13) References:

1. Signal recognition particle components in the nucleolus.  |  Politz, JC., et al. 2000. Proc Natl Acad Sci U S A. 97: 55-60. PMID: 10618370
2. The nucleolus and the four ribonucleoproteins of translation.  |  Pederson, T. and Politz, JC. 2000. J Cell Biol. 148: 1091-5. PMID: 10725320
3. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.  |  Wild, K., et al. 2001. Science. 294: 598-601. PMID: 11641499
4. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.  |  Iakhiaeva, E., et al. 2006. Protein Sci. 15: 1290-302. PMID: 16672232
5. The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins.  |  Herz, J., et al. 1990. FEBS Lett. 276: 103-7. PMID: 1702390
6. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA.  |  Lingelbach, K., et al. 1988. Nucleic Acids Res. 16: 9431-42. PMID: 2460823
7. Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.  |  Walter, P. and Blobel, G. 1983. J Cell Biol. 97: 1693-9. PMID: 6196367
8. The uRNA database.  |  Zwieb, C. 1997. Nucleic Acids Res. 25: 102-3. PMID: 9016512
9. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites.  |  Gowda, K., et al. 1998. Gene. 207: 197-207. PMID: 9511762

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SRP68 Antibody (4-YD13) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SRP68 Antibody (4-YD13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SRP68 Antibody (4-YD13) Specifications

Alternate Product Name: SRP68

Product Clone Name: 4-YD13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 531-628

Epitope Target: SRP68

Epitope Species: human

Product Reactivity/Detection: SRP68

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SRP68 Antibody (4-YD13): N/A