SREC-II Activators
SREC-II Activators are an assortment of chemical compounds that facilitate the enhancement of SREC-II, a scavenger receptor integral to endocytic and signaling pathways. The activation of SREC-II by these compounds is achieved through various intricate biochemical mechanisms. Forskolin, by raising the levels of cyclic AMP, indirectly amplifies SREC-II activity by fostering PKA activation, which may phosphorylate SREC-II, thus augmenting its ligand-binding efficiency and endocytic functions. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which is likely to phosphorylate SREC-II, enhancing its capability to mediate cellular uptake. SREC-II's activity is further influenced by Ionomycin, which, by increasing intracellular calcium, can activate calcium-dependent protein kinases to potentially phosphorylate and invigorate SREC-II. Spermine, through its interaction with cellular membranes and ion channels, can modulate signaling pathways that indirectly bolster SREC-II function. Moreover, Resveratrol's activation of SIRT1 may lead to the deacetylation of SREC-II, subtly tuning its role in lipoprotein particle uptake.
The intricate signaling landscape that SREC-II operates within is further shaped by compounds such as LY294002, which, by inhibiting PI3K, could lead to a compensatory enhancement of SREC-II's endocytic function. Epigallocatechin Gallate (EGCG) inhibits protein kinases that compete with SREC-II, potentially amplifying its signaling and endocytic roles. U0126 disrupts the MAPK/ERK pathway, which could result in an increase in SREC-II activity, as this pathway influences receptor functions. Sildenafil, through PDE5 inhibition, causes an upsurge in cAMP and cGMP, activating PKA and PKG that could phosphorylate and thus enhance the functions of SREC-II. Sulforaphane, by activating the Nrf2 pathway, could upregulate SREC-II as part of a cellular defense mechanism, while Curcumin's inhibition of NF-κB signaling might indirectly promote SREC-II activity. Finally, nitric oxide donors like SNAP, by increasing cGMP levels and activating PKG, can phosphorylate SREC-II, enhancing its signal transduction functions related to scavenger receptor activity. Collectively, these chemical activators orchestrate a symphony of cellular signals that converge on the potentiation of SREC-II's crucial tasks in cellular endocytosis and signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate SREC-II, thereby enhancing its ligand-binding capacity and promoting its activity in endocytosis and scavenging. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of SREC-II, which may increase its affinity for ligands or its capacity to mediate endocytosis in cellular signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that escalates intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which may phosphorylate SREC-II and enhance its receptor-mediated activities. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine known to stabilize cell membranes and interact with various ion channels. Its cellular effects can promote signaling cascades that indirectly enhance the functional activity of SREC-II by affecting membrane dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate SIRT1, which is involved in the deacetylation of proteins. SIRT1 activation could lead to the deacetylation of SREC-II, influencing its function in cellular uptake of lipoprotein particles. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that alters PI3K/Akt signaling. By inhibiting this pathway, there could be a compensatory upregulation of SREC-II activity as the cell seeks to maintain homeostatic receptor-mediated endocytic processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit certain protein kinases. This inhibition could lead to a reduced phosphorylation of downstream targets that normally compete with SREC-II, thereby potentially enhancing SREC-II's role in signaling and endocytosis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in cellular defense mechanisms. Activation of Nrf2 could upregulate SREC-II activity as part of an adaptive response to increased oxidative stress, leading to increased clearance of modified lipoproteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit NF-κB signaling. This inhibition may promote SREC-II activity indirectly as NF-κB can regulate the expression of various receptors and their ligands, potentially affecting the functional activity of SREC-II in endocytosis. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
Nitric oxide donors lead to the activation of soluble guanylate cyclase and increase cGMP levels. Elevated cGMP can activate PKG, which may then phosphorylate and enhance SREC-II activity in signal transduction related to scavenger receptor functions. | ||||||