Date published: 2026-1-7

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SR-3B Activators

SR-3B activators primarily employ a mechanism of action that involves the modulation of serotonin distribution. This modulation is achieved by the antagonism of serotonin receptors that are not SR-3B. Activators such as MDL 72222, Granisetron, Ondansetron, Dolasetron, Tropisetron, Ramosetron, Palonosetron, Alosetron, AS-8112, and Zacopride work by blocking serotonin receptors other than SR-3B. This antagonistic approach increases the availability of serotonin, the natural ligand for SR-3B, promoting targeted interaction and activation of SR-3B.The overall effect produced by these chemicals is a strategic redirection of serotonin towards SR-3B, thereby enhancing its activation. The drug Metoclopramide, a dopamine receptor antagonist, also affects serotonin receptors. This dual action can enhance overall serotonin neurotransmission, increasing the chance of SR-3B interaction with serotonin and subsequent activation. All these compounds enhance the functionality of SR-3B by increasing the availability of serotonin for SR-3B receptors, which can lead to the activation of the protein and the subsequent downstream effects.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SR 57227 hydrochloride

77145-61-0sc-204301
sc-204301A
10 mg
50 mg
$151.00
$570.00
(0)

SR 57227 hydrochloride, classified as an SR-3B compound, showcases remarkable solubility characteristics that facilitate its interaction with polar solvents. Its unique steric configuration promotes specific molecular alignments, enhancing its reactivity in nucleophilic substitution reactions. The compound's ability to form transient complexes with various nucleophiles is influenced by its electronic distribution, leading to distinct reaction kinetics. Additionally, its strong hydrogen bonding capabilities contribute to its stability and reactivity in diverse chemical environments.

RS 56812 hydrochloride

143137-35-3sc-361315
sc-361315A
10 mg
50 mg
$200.00
$902.00
(0)

RS 56812 hydrochloride, an SR-3B compound, exhibits intriguing electrostatic interactions that enhance its affinity for charged species. Its unique structural features allow for selective binding with anions, influencing its reactivity in electrophilic addition reactions. The compound's dynamic conformational flexibility plays a crucial role in facilitating rapid reaction pathways, while its capacity to engage in π-stacking interactions further modulates its chemical behavior in various environments.

Ondansetron

99614-02-5sc-201127
sc-201127A
10 mg
50 mg
$82.00
$333.00
1
(0)

A serotonin 5-HT3 receptor antagonist. It can increase the availability of serotonin to interact with SR-3B, potentially leading to its activation.

Tropisetron hydrochloride

105826-92-4sc-204930
sc-204930A
10 mg
50 mg
$96.00
$571.00
2
(0)

A serotonin 5-HT3 receptor antagonist. It can increase the availability of serotonin to interact with SR-3B, potentially leading to its activation.

Metoclopramide

364-62-5sc-358363
100 g
$465.00
1
(0)

A dopamine receptor antagonist that also acts on serotonin receptors. It can increase the availability of serotonin to interact with SR-3B, potentially leading to its activation.