SR-3B Antibody (H-9): sc-390642
- SR-3B Antibody (H-9) is a mouse monoclonal IgG1 κ SR-3B antibody provided at 200 µg/ml
- raised against amino acids 168-231 mapping within an internal region of SR-3B of mouse origin
- SR-3B Antibody (H-9) is recommended for detection of SR-3B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SR-3B Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for SR-3B Antibody (H-9) for WB applications. This reagent is now offered in a bundle with SR-3B Antibody (H-9) (see ordering information below).
SR-3B Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-3B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SR-3B (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-3B protein, a 441 amino acid subunit of the serotonin receptor, plays a crucial role in mediating fast, depolarizing responses in neurons upon activation, which is essential for neurotransmission and various physiological processes. SR-3B protein is predominantly expressed in the brain, particularly in regions such as the hippocampus, thalamus, caudate nucleus, and amygdala, while showing no expression in the heart, placenta, lung, liver, skeletal muscle, or pancreas. SR-3B protein′s specific localization in the central nervous system highlights SR-3B′s importance in modulating neuronal excitability and synaptic transmission, which are vital for cognitive functions and emotional regulation. Understanding SR-3B protein′s role in these processes can provide insights into SR-3B′s involvement in psychiatric disorders and other neurological conditions, making SR-3B (H-9) monoclonal antibody a valuable tool for researchers studying serotonin signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SR-3B Antibody (H-9) References:
- The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. | Dubin, AE., et al. 1999. J Biol Chem. 274: 30799-810. PMID: 10521471
- Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy. | Mott, DD., et al. 2001. J Physiol. 535: 427-43. PMID: 11533135
- A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. | Kelley, SP., et al. 2003. Nature. 424: 321-4. PMID: 12867984
- A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. | Melke, J., et al. 2003. Arch Gen Psychiatry. 60: 1017-23. PMID: 14557147
- The 5-HT3B subunit is a major determinant of serotonin-receptor function. | Davies, PA., et al. 1999. Nature. 397: 359-63. PMID: 9950429
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SR-3B Antibody (H-9) | sc-390642 | 200 µg/ml | $322.00 | |||
SR-3B Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-526182 | 200 µg Ab; 10 µg BP | $361.00 | |||
SR-3B Antibody (H-9) AC | sc-390642 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SR-3B Antibody (H-9) HRP | sc-390642 HRP | 200 µg/ml | $322.00 | |||
SR-3B Antibody (H-9) FITC | sc-390642 FITC | 200 µg/ml | $336.00 | |||
SR-3B Antibody (H-9) PE | sc-390642 PE | 200 µg/ml | $349.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 488 | sc-390642 AF488 | 200 µg/ml | $364.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 546 | sc-390642 AF546 | 200 µg/ml | $364.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 594 | sc-390642 AF594 | 200 µg/ml | $364.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 647 | sc-390642 AF647 | 200 µg/ml | $364.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 680 | sc-390642 AF680 | 200 µg/ml | $364.00 | |||
SR-3B Antibody (H-9) Alexa Fluor® 790 | sc-390642 AF790 | 200 µg/ml | $364.00 |