Date published: 2025-11-21

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SPTLC Inhibitors

Santa Cruz Biotechnology now offers a broad range of SPTLC inhibitors for use in various applications. SPTLC inhibitors, or serine palmitoyltransferase inhibitors, are a crucial category of compounds that inhibit the enzyme serine palmitoyltransferase (SPT). This enzyme is a key component in the biosynthesis of sphingolipids, which are essential components of cell membranes and play critical roles in cell signaling and regulation. In scientific research, SPTLC inhibitors are used to study the pathways and mechanisms of sphingolipid metabolism and their impact on cellular processes. These inhibitors are vital in explaining the function of sphingolipids in diverse biological systems, including their roles in cell growth, differentiation, and apoptosis. The use of SPTLC inhibitors has expanded our understanding of lipid biology, contributing significantly to fields such as biochemistry, molecular biology, and cell biology. Researchers employ these inhibitors to dissect the complex networks of lipid signaling and to explore the regulatory mechanisms that govern cellular responses to environmental and internal stimuli. Additionally, SPTLC inhibitors serve as valuable tools in the development of analytical methods for detecting and quantifying sphingolipids in biological samples. View detailed information on our available SPTLC inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Cycloserine

339-72-0sc-201387A
sc-201387
25 mg
100 mg
$215.00
$300.00
4
(1)

L-Cycloserine, as a sptlc, showcases remarkable characteristics through its ability to participate in intramolecular hydrogen bonding, which stabilizes its conformation. The presence of amino groups facilitates nucleophilic attack in various reactions, while its unique cyclic structure allows for conformational flexibility. This compound's polar and non-polar regions contribute to its solubility profile, influencing its reactivity and interaction with diverse chemical environments, thereby affecting reaction dynamics.

Myriocin (ISP-1)

35891-70-4sc-201397
10 mg
$106.00
8
(2)

Myriocin (ISP-1) functions as a sptlc by selectively inhibiting serine palmitoyltransferase, a key enzyme in sphingolipid biosynthesis. Its unique structure allows for specific binding interactions with the enzyme's active site, disrupting substrate access. The compound's hydrophobic regions enhance its affinity for lipid membranes, influencing its distribution and interaction kinetics. Additionally, Myriocin's stereochemistry plays a crucial role in modulating enzyme activity, impacting metabolic pathways.