L-Cycloserine (CAS 339-72-0)
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L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine (sc-221470). Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication.
L-Cycloserine (CAS 339-72-0) References
- L-cycloserine slows the clinical and pathological course in mice with globoid cell leukodystrophy (twitcher mice). | LeVine, SM., et al. 2000. J Neurosci Res. 60: 231-6. PMID: 10740228
- Effect of L-cycloserine on cellular responses mediated by macrophages and T cells. | Cho, JY. 2007. Biol Pharm Bull. 30: 2105-12. PMID: 17978484
- Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor. | Shukla, GS., et al. 1991. Biochim Biophys Acta. 1083: 101-8. PMID: 1827738
- The effects of l-cycloserine on gangliosides in the developing mouse brain. | Wilson, MS., et al. 1987. Neurochem Int. 11: 169-74. PMID: 20501158
- Exposure to L-cycloserine incurs survival costs and behavioral alterations in Aedes aegypti females. | Belloni, V. and Scaraffia, PY. 2014. Parasit Vectors. 7: 373. PMID: 25129074
- L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. | Polc, P., et al. 1986. Neuropharmacology. 25: 411-8. PMID: 3012401
- Pyruvate decarboxylating action of L-cycloserine. The significance of this in understanding its metabolic inhibitory action. | Pérez-Sala, D., et al. 1986. J Biol Chem. 261: 13969-72. PMID: 3771514
- Effect of L-cycloserine on brain GABA metabolism. | Wood, JD., et al. 1978. Can J Physiol Pharmacol. 56: 62-8. PMID: 638858
- Isolation of L-cycloserine from Erwinia uredovora. | Shoji, J., et al. 1984. J Antibiot (Tokyo). 37: 1198-203. PMID: 6501090
- Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo. | Sundaram, KS. and Lev, M. 1984. J Neurochem. 42: 577-81. PMID: 6693888
- L-cycloserine inhibition of sphingolipid synthesis in the anaerobic bacterium Bacteroides levii. | Sundaram, KS. and Lev, M. 1984. Biochem Biophys Res Commun. 119: 814-9. PMID: 6712658
- Effect of L-cycloserine on cortical neurons in the rat. | Haas, HL. and Wieser, HG. 1980. Eur J Pharmacol. 61: 79-83. PMID: 7353584
- L-cycloserine, an inhibitor of sphingolipid biosynthesis, inhibits HIV-1 cytopathic effects, replication, and infectivity. | Mizrachi, Y., et al. 1996. J Acquir Immune Defic Syndr Hum Retrovirol. 11: 137-41. PMID: 8556395
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Cycloserine, 25 mg | sc-201387A | 25 mg | $215.00 | |||
L-Cycloserine, 100 mg | sc-201387 | 100 mg | $300.00 |