SPLUNC2 Inhibitors
The chemical class broadly referred to as SPLUNC2 Inhibitors encompasses a range of compounds that can indirectly influence the activity of SPLUNC2, a protein thought to be involved in mucosal immunity and the innate defense against pathogens. These chemicals typically exert their effects not directly on SPLUNC2 itself, but rather by modulating the biological pathways and cellular processes in which SPLUNC2 participates. Amiloride, for example, can influence ion transport across epithelial surfaces, a process that SPLUNC2 may also affect through its interactions with epithelial sodium channels. This action can alter the ionic balance and hydration state of mucosal surfaces, which are critical parameters in mucosal immunity and defense. Benzalkonium Chloride, on the other hand, is known for its surfactant and antimicrobial properties and can disrupt microbial membranes, which may affect the functional context in which SPLUNC2 operates.
Compounds like Xylitol and Glycyrrhizin can alter pathogen adhesion to mucosal surfaces and modulate immune responses, respectively, which may impact the antimicrobial landscape and immunomodulatory functions of SPLUNC2. Other compounds such as Curcumin, Resveratrol, Ebselen, Quercetin, and Isothiocyanates possess anti-inflammatory and antioxidant properties that can modulate the inflammatory pathways and oxidative stress responses, influencing SPLUNC2's role in these processes. Furthermore, common anti-inflammatory drugs like Ibuprofen, as well as more specific anti-inflammatory agents like Sulforaphane and EGCG, can indirectly impact SPLUNC2 by affecting inflammation-related signaling pathways. SPLUNC2's involvement in airway inflammation means that modulation of these signaling pathways can alter the conditions under which SPLUNC2 operates within the respiratory tract. Overall, while these compounds do not inhibit SPLUNC2 directly, their actions on related biological functions and pathways can modulate the activity and role of SPLUNC2 in mucosal immunity and the body's defense mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
A diuretic that inhibits epithelial sodium channels, possibly affecting SPLUNC2's role in fluid balance and mucosal immunity. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
A compound from licorice root that can modulate immune responses, possibly impacting SPLUNC2's immunomodulatory functions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
An anti-inflammatory compound that may affect SPLUNC2's regulation of inflammation and mucosal defense. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
An antioxidant that can modulate inflammatory responses, potentially affecting SPLUNC2's role in airway inflammation. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
An anti-inflammatory compound with antioxidant properties that can influence inflammatory pathways associated with SPLUNC2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid with antioxidant and anti-inflammatory properties that may affect the activity of SPLUNC2 in airway inflammation. | ||||||
Allyl isothiocyanate | 57-06-7 | sc-252361 sc-252361A sc-252361B | 5 g 100 g 500 g | $44.00 $67.00 $119.00 | 3 | |
Compounds found in cruciferous vegetables that can modulate inflammation and potentially affect SPLUNC2. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
A nonsteroidal anti-inflammatory drug that may indirectly impact SPLUNC2 through its effects on inflammation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate with anti-inflammatory properties that can influence pathways involving SPLUNC2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea with anti-inflammatory effects, which may affect SPLUNC2's role in inflammation. | ||||||