SPATA32 Inhibitors
SPATA32 inhibitors includes molecules like Testolactone and Ketoconazole, which exert influence on steroid biosynthesis by targeting key enzymes such as aromatase and cytochrome P450, respectively. By modulating the synthesis that regulate testicular function, these inhibitors may alter the cellular environment in which SPATA32 operates. Sirolimus, which acts upon the mTOR pathway, has implications for cellular growth and proliferation, providing a means by which SPATA32 activity may be indirectly affected if the protein is part of this broader regulatory network. Similarly, Vinblastine and Paclitaxel affect the dynamics of microtubule assembly and stability, a critical aspect of cell division. If SPATA32 is associated with the proliferative stages of spermatogenesis, these inhibitors could modulate its function by altering the microtubule architecture.
Alsterpaullone, by inhibiting cyclin-dependent kinases, and Bicalutamide, an androgen receptor antagonist, represent mechanisms by which cell cycle regulation and androgen signaling can be influenced. Such interventions suggest a potential for altering SPATA32 activity if it is linked with these aspects of cellular control. Other compounds, including Mitotane and Gonadotropin-releasing antagonists, affect adrenal and gonadal levels, which could indirectly modulate SPATA32 if it is sensitive to hormonal regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Inhibits steroid biosynthesis by blocking cytochrome P450 enzymes, which could reduce testosterone levels and alter SPATA32 function if androgen-regulated. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Acts on mTOR signaling, which is involved in cell growth and proliferation. Sirolimus can inhibit this pathway, potentially affecting SPATA32 if mTOR-linked. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Disrupts microtubule formation, which can affect cell division. This action can influence SPATA32 if it is associated with spermatogenic cell division. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Inhibits cyclin-dependent kinases, which are vital for cell cycle progression. This inhibition could affect SPATA32 if it is involved in cell cycle control in spermatogenesis. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Acts as an aldosterone antagonist and can affect mineralocorticoid pathways; could alter SPATA32 activity if there is a regulatory overlap in testicular cells. | ||||||
Trilostane | 13647-35-3 | sc-208469 sc-208469A | 10 mg 100 mg | $224.00 $1193.00 | 2 | |
Inhibits 3β-hydroxysteroid dehydrogenase, which is crucial for steroid biosynthesis, potentially affecting SPATA32 activity in steroid-dependent pathways. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and can disrupt cell division, potentially affecting SPATA32 if it plays a role in spermatogenic division. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $41.00 $143.00 | 27 | |
Androgen receptor antagonist that can inhibit androgen signaling; could affect SPATA32 function if it is androgen-responsive. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $71.00 $163.00 | 1 | |
Inhibits adrenocortical function, which may indirectly affect testicular function and SPATA32 activity due to regulatory mechanisms. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $46.00 $153.00 $168.00 $515.00 $923.00 | 4 | |
Blocks androgen receptors and inhibits androgenic activity, which could influence SPATA32 if it is androgen-dependent. | ||||||