SPATA19 Inhibitors
SPATA19 inhibitors are a class of chemical compounds that target and inhibit the function of the SPATA19 protein, a spermatogenesis-associated protein primarily expressed in testicular tissues. The SPATA19 gene has been shown to play a significant role in the regulation of processes critical for spermatogenesis, the complex and highly regulated process of sperm cell development. SPATA19 is involved in the maintenance of mitochondrial function and cellular energy homeostasis, essential factors in the maturation and viability of spermatozoa. Inhibiting SPATA19 can disrupt these processes, resulting in alterations in mitochondrial integrity and possibly interfering with the regulation of oxidative stress within germ cells. SPATA19's mitochondrial interactions suggest a deeper involvement in cell survival and metabolic balance, making its inhibitors a focal point of biochemical interest in studies involving cellular metabolism.
On a molecular level, SPATA19 inhibitors can work by binding to the active sites or regulatory regions of the SPATA19 protein, thereby blocking its natural function. These inhibitors often exhibit a specific affinity for certain structural motifs or domains within SPATA19, which are critical for its binding to mitochondrial proteins and its overall activity within the cell. The inhibition of SPATA19 may induce changes in mitochondrial dynamics, leading to downstream effects on cellular respiration and energy production. Structural studies of SPATA19 and its inhibitors are key to understanding how small molecules can modulate its activity, providing insight into the protein's role in broader cellular functions such as apoptosis, stress response, and metabolic regulation. Understanding the specificity and mechanism of these inhibitors at the molecular level is crucial for furthering the knowledge of mitochondrial biology and cellular energy pathways.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
PIK-75 is a selective inhibitor of PI3Kα and PI3Kγ isoforms, which could indirectly affect SPATA19 by modifying signaling pathways involved in cell growth and survival, potentially impacting germ cell development. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is a potent ATP-competitive inhibitor of mTOR kinase activity, which could lead to alterations in cell growth and autophagy, indirectly affecting SPATA19's role in spermatogenesis. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $90.00 $275.00 | 12 | |
BI-D1870 is an inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms, which are downstream effectors of the ERK/MAPK pathway. Inhibition of RSK may indirectly impact SPATA19 by modifying transcription and cell cycle regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β receptor type I (ALK5), which could alter the TGF-β signaling pathway, potentially impacting cellular processes that indirectly affect SPATA19 activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD0332991, also known as palbociclib, is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Inhibition of CDKs may indirectly influence SPATA19 by altering the cell cycle regulation in spermatogenic cells. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is a non-competitive inhibitor of neutral sphingomyelinase (nSMase), which may impact sphingolipid signaling pathways, thereby potentially influencing processes in which SPATA19 is involved. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is a potent and selective mTOR inhibitor that affects cell growth and metabolism. Its inhibition of mTOR may indirectly influence SPATA19 by altering the cellular environment in germ cells. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, which may indirectly affect SPATA19 by modifying inflammation and cell survival pathways, potentially influencing spermatogenesis. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $175.00 $700.00 | 9 | |
PF-4708671 is a selective inhibitor of the p70 S6 kinase 1 (S6K1), which could indirectly affect SPATA19 by modulating signaling pathways that control protein synthesis and cell growth. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a tankyrase inhibitor that stabilizes axin and inhibits Wnt/β-catenin signaling, which may indirectly impact SPATA19 by affecting cell proliferation and differentiation pathways. | ||||||