SPANX-B2 Inhibitors

The chemical class of SPANX-B2 inhibitors comprises a diverse array of compounds with potent anti-inflammatory and anticancer properties. These inhibitors target SPANX-B2 expression through various mechanisms, ultimately inhibiting cancer cell growth and progression. One prominent group of inhibitors within this class includes polyphenols such as Curcumin, Resveratrol, and EGCG. These compounds inhibit SPANX-B2 expression by suppressing the activation of NF-κB, a transcription factor involved in inflammation and cancer development. By blocking NF-κB activation, polyphenols effectively reduce the transcription of genes associated with cancer progression.

Flavonoids like Quercetin and Genistein also belong to the class of SPANX-B2 inhibitors. These compounds interfere with estrogen receptor signaling and modulate inflammatory pathways, leading to the inhibition of SPANX-B2 expression. Additionally, selective inhibitors such as Celecoxib and Betulinic acid target specific enzymes like COX-2 and AMPK, respectively, which play crucial roles in inflammation-driven cancer development. By inhibiting these enzymes, these compounds suppress SPANX-B2 expression and attenuate cancer cell growth.