SorCS2 Activators

Sortilin-related VPS10 domain-containing receptor 2 (SORCS2) is a protein that is encoded by the SORCS2 gene in humans. It is part of the VPS10 domain receptor family, which is known for its role in intracellular protein trafficking. SORCS2 is predominantly expressed in the central nervous system and is thought to have important functions in neurodevelopment and neuronal signaling.The protein structure of SORCS2 features a VPS10 domain, which is significant for its role in binding ligands and directing them to their appropriate destinations within the cell. This domain is a hallmark of proteins involved in the sorting of other proteins through endosomes and lysosomes, suggesting a role for SORCS2 in similar transport pathways.

SORCS2 has been implicated in synaptic function and plasticity, with studies suggesting that it may influence neurotransmitter receptor trafficking and thus modulate synaptic strength and memory formation. It may also have a role in neurodevelopmental processes,influencing neuronal survival, differentiation, and migration.Research into SORCS2 has also highlighted its involvement in neurodegenerative diseases and psychiatric disorders. Variations in the gene encoding SORCS2 have been associated with susceptibility to these conditions, although the exact mechanisms by which SORCS2 contributes to disease pathology remain an active area of investigation.