SorCS2 Antibody (A-10): sc-398412
- SorCS2 Antibody (A-10) is a mouse monoclonal IgG2a κ SorCS2 antibody provided at 200 µg/ml
- raised against amino acids 755-1012 mapping within an internal region of SorCS2 of human origin
- SorCS2 Antibody (A-10) is recommended for detection of SorCS2 of human origin by WB, IP, IF and ELISA
- Anti-SorCS2 Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for SorCS2 Antibody (A-10) for WB applications. This reagent is now offered in a bundle with SorCS2 Antibody (A-10) (see ordering information below).
QUICK LINKS
SorCS2 Antibody (A-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects SorCS2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SorCS2 antibody (A-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SorCS2, a single-pass type I membrane protein consisting of 1,150 amino acids, plays a crucial role in the central nervous system and is predominantly expressed in the brain and kidney. SorCS2 structure includes six BNR repeats and a single PKD domain, which are essential for intracellular trafficking and signaling. SorCS2 belongs to a family of receptors sharing homology with mosaic receptor SorLA and neurotensin receptor sortilin, characterized by a common VPS10 domain. This domain enables SorCS2 to bind and transport various ligands, influencing neuronal development and function. SorCS2 gene is located on human chromosome 4, a region notable for extensive gene deserts, which are areas devoid of protein-coding genes. Understanding SorCS2 structure and function is important for elucidating neurobiological roles and potential implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SorCS2 Antibody (A-10) References:
- Identification and characterization of SorCS, a third member of a novel receptor family. | Hermey, G., et al. 1999. Biochem Biophys Res Commun. 266: 347-51. PMID: 10600506
- Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails. | Hermey, G. and Schaller, HC. 2000. Biochim Biophys Acta. 1491: 350-4. PMID: 10760602
- Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain. | Rezgaoui, M., et al. 2001. Mech Dev. 100: 335-8. PMID: 11165493
- Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. | Hermey, G., et al. 2001. Neuroreport. 12: 29-32. PMID: 11201086
- The three sorCS genes are differentially expressed and regulated by synaptic activity. | Hermey, G., et al. 2004. J Neurochem. 88: 1470-6. PMID: 15009648
- Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. | Hermey, G., et al. 2006. Biochem J. 395: 285-93. PMID: 16393139
- VPS10P-domain receptors - regulators of neuronal viability and function. | Willnow, TE., et al. 2008. Nat Rev Neurosci. 9: 899-909. PMID: 19002190
- The Vps10p-domain receptor family. | Hermey, G. 2009. Cell Mol Life Sci. 66: 2677-89. PMID: 19434368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SorCS2 Antibody (A-10) | sc-398412 | 200 µg/ml | $322.00 | |||
SorCS2 Antibody (A-10): m-IgG2a BP-HRP Bundle | sc-545972 | 200 µg Ab; 10 µg BP | $361.00 | |||
SorCS2 Antibody (A-10) AC | sc-398412 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SorCS2 Antibody (A-10) HRP | sc-398412 HRP | 200 µg/ml | $322.00 | |||
SorCS2 Antibody (A-10) FITC | sc-398412 FITC | 200 µg/ml | $336.00 | |||
SorCS2 Antibody (A-10) PE | sc-398412 PE | 200 µg/ml | $349.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 488 | sc-398412 AF488 | 200 µg/ml | $364.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 546 | sc-398412 AF546 | 200 µg/ml | $364.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 594 | sc-398412 AF594 | 200 µg/ml | $364.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 647 | sc-398412 AF647 | 200 µg/ml | $364.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 680 | sc-398412 AF680 | 200 µg/ml | $364.00 | |||
SorCS2 Antibody (A-10) Alexa Fluor® 790 | sc-398412 AF790 | 200 µg/ml | $364.00 |