SorCS2 Activators
Sortilin-related VPS10 domain-containing receptor 2 (SORCS2) is a protein that is encoded by the SORCS2 gene in humans. It is part of the VPS10 domain receptor family, which is known for its role in intracellular protein trafficking. SORCS2 is predominantly expressed in the central nervous system and is thought to have important functions in neurodevelopment and neuronal signaling.The protein structure of SORCS2 features a VPS10 domain, which is significant for its role in binding ligands and directing them to their appropriate destinations within the cell. This domain is a hallmark of proteins involved in the sorting of other proteins through endosomes and lysosomes, suggesting a role for SORCS2 in similar transport pathways.
SORCS2 has been implicated in synaptic function and plasticity, with studies suggesting that it may influence neurotransmitter receptor trafficking and thus modulate synaptic strength and memory formation. It may also have a role in neurodevelopmental processes,influencing neuronal survival, differentiation, and migration.Research into SORCS2 has also highlighted its involvement in neurodegenerative diseases and psychiatric disorders. Variations in the gene encoding SORCS2 have been associated with susceptibility to these conditions, although the exact mechanisms by which SORCS2 contributes to disease pathology remain an active area of investigation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may increase intracellular cAMP levels, which can activate protein kinase A (PKA) and potentially upregulate SORCS2 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression through its role in neuronal growth and development, potentially affecting SORCS2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methylation inhibitor, 5-azacytidine could induce SORCS2 expression by altering epigenetic regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor may upregulate gene expression, including SORCS2, by altering chromatin structure. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, another histone deacetylase inhibitor, could potentially enhance SORCS2 expression through epigenetic modifications. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect glycogen synthase kinase-3 (GSK-3) activity and may impact gene expression related to neurogenesis, possibly including SORCS2. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
As an inhibitor of neurotrophin receptors, K252a can affect downstream signaling pathways and potentially influence SORCS2 expression. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), which can raise cAMP levels and might affect SORCS2 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
This estrogen may regulate gene expression in the nervous system and could potentially upregulate SORCS2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
This cAMP analog can mimic the effects of endogenous cAMP and potentially upregulate SORCS2 expression. | ||||||