Sodium Channel Modulators
Items 51 to 60 of 74 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SDZ-201106 (±), (DPI-201106) | 97730-95-5 | sc-201072 sc-201072A sc-201072B | 25 mg 100 mg 250 mg | $67.00 $217.00 $490.00 | 2 | |
SDZ-201106 (±), also known as DPI-201106, functions as a sodium channel modulator through its ability to interact with specific binding sites on the channel protein. This interaction stabilizes certain conformations, effectively altering the channel's gating kinetics. The compound's unique molecular architecture facilitates selective engagement with the channel, influencing ion flow and contributing to the modulation of excitatory signals in cellular environments. Its distinct binding affinity enhances the precision of sodium ion regulation. | ||||||
Rufinamide | 106308-44-5 | sc-212794 | 10 mg | $156.00 | ||
Rufinamide acts as a sodium channel modulator by selectively binding to the inactivated state of voltage-gated sodium channels. This binding alters the channel's recovery kinetics, prolonging the inactivation phase and reducing excitability. Its unique structural features enable it to preferentially stabilize specific channel conformations, thereby fine-tuning the flow of sodium ions. This modulation impacts neuronal signaling dynamics, showcasing its intricate role in ion channel behavior. | ||||||
Ibutilide Fumarate | 122647-32-9 | sc-211627 | 10 mg | $250.00 | ||
Ibutilide Fumarate functions as a sodium channel modulator by interacting with the voltage-gated sodium channels, particularly influencing their activation and inactivation kinetics. Its unique molecular structure allows it to preferentially bind to specific channel states, enhancing the duration of sodium ion influx. This selective modulation alters the excitability of cells, demonstrating its complex influence on ion transport mechanisms and cellular electrical activity. | ||||||
Sipatrigine | 130800-90-7 | sc-362796 sc-362796A | 10 mg 50 mg | $185.00 $772.00 | ||
Sipatrigine acts as a sodium channel modulator by selectively binding to the inactivated state of voltage-gated sodium channels, thereby stabilizing them and prolonging their inactive duration. This unique interaction alters the kinetics of channel recovery, leading to a distinct modulation of neuronal excitability. Its specific binding affinity influences ion flow dynamics, contributing to a nuanced regulation of cellular signaling pathways and electrical properties. | ||||||
KC 12291 hydrochloride | 181936-98-1 | sc-204028 sc-204028A | 10 mg 50 mg | $175.00 $739.00 | ||
KC 12291 hydrochloride functions as a sodium channel modulator by engaging with the channel's conformational states, particularly favoring the inactivated form. This selective interaction disrupts the normal gating mechanisms, resulting in altered ion permeability and modified action potential propagation. Its unique binding characteristics influence the kinetics of channel reopening, thereby affecting the overall excitability of neuronal networks and cellular communication. | ||||||
KB-R7943 MESYLATE | 182004-65-5 | sc-202681 | 10 mg | $157.00 | 4 | |
KB-R7943 MESYLATE acts as a sodium channel modulator by selectively stabilizing the inactivated state of the channel, which alters the dynamics of ion flow. This compound exhibits unique binding affinities that influence the channel's conformational transitions, leading to a distinct modulation of excitatory signaling pathways. Its interaction with specific amino acid residues within the channel may also impact the rate of desensitization, further affecting cellular excitability and signaling efficiency. | ||||||
Ralfinamide mesylate | 202825-45-4 | sc-362788 sc-362788A | 10 mg 50 mg | $86.00 $346.00 | ||
Ralfinamide mesylate functions as a sodium channel modulator by engaging in specific interactions with the channel's voltage-sensing domains. This compound alters the kinetics of channel activation and inactivation, promoting a unique stabilization of the closed state. Its distinct molecular structure allows for selective binding, influencing the overall ion permeability and contributing to altered neuronal excitability. The modulation of these pathways can lead to significant changes in cellular signaling dynamics. | ||||||
Butacaine Sulphate | 149-15-5 | sc-210971 | 1 g | $360.00 | ||
Butacaine Sulphate acts as a sodium channel modulator by selectively binding to the channel's pore region, influencing ion flow and gating mechanisms. Its unique molecular configuration facilitates a distinct interaction with the channel's lipid environment, enhancing its stability in various conformations. This compound exhibits notable effects on the kinetics of sodium ion conduction, leading to altered depolarization thresholds and impacting cellular excitability and signaling pathways. | ||||||
Lappaconitine hydrobromide | 97792-45-5 | sc-300905 sc-300905A | 10 mg 100 mg | $780.00 $1000.00 | ||
Lappaconitine hydrobromide functions as a sodium channel modulator by engaging with specific binding sites on the channel, altering its conformational dynamics. This compound exhibits a unique affinity for the inactivated state of sodium channels, which influences the recovery kinetics and prolongs the refractory period. Its distinct molecular interactions with surrounding lipids enhance channel stability, thereby affecting ion permeability and excitability in neuronal tissues. | ||||||
Allethrin | 584-79-2 | sc-202921 sc-202921A | 10 mg 25 mg | $31.00 $42.00 | ||
Allethrin acts as a sodium channel modulator by selectively binding to the channel's voltage-sensing domains, leading to altered gating mechanisms. This compound exhibits a unique ability to stabilize the inactivated state of sodium channels, which modifies the activation threshold and influences the duration of action potentials. Its interactions with lipid bilayers can also affect channel density and distribution, impacting overall neuronal excitability and signal propagation. | ||||||