SNF2L Inhibitors

SNF2L inhibitors are chemical entities that can diminish the functional activity of SNF2L, a protein involved in chromatin remodeling and DNA repair. These inhibitors primarily include DNA-binding antineoplastic antibiotics and inhibitors of histone deacetylases (HDACs) and DNA methyltransferase. By inhibiting these specific cellular processes and signaling molecules, the inhibitors can influence SNF2L's function without directly blocking its activity.

Mithramycin A, an antineoplastic antibiotic, can inhibit the transcription of a variety of genes. Given that SNF2Lparticipates in chromatin remodeling, the disruption of gene transcription by Mithramycin A can lead to a decrease in SNF2L activity. Similarly, Trichostatin A, a potent inhibitor of class I and II HDACs, can disrupt the chromatin remodeling processes that SNF2L is involved in, leading to its decreased activity. The nucleoside analogue 5-Azacytidine incorporates into DNA and RNA and inhibits DNA methyltransferase, contributing to hypomethylation. SNF2L's role in DNA methylation and chromatin remodeling can be affected by this inhibition, leading to a decrease in its activity.