Date published: 2025-10-23

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SMYD3 Activators

SMYD3 activators encompass a diverse class of chemicals designed to modulate the activity of SMYD3, a key regulator of epigenetic modifications and cellular processes. ML324, a chemical activator, indirectly influences SMYD3 activity by affecting the Wnt signaling pathway. Wnt signaling modulation by ML324 can lead to the activation of SMYD3, potentially influencing its epigenetic functions and downstream cellular processes governed by SMYD3-mediated chromatin modifications. AMI-1, another activator, indirectly activates SMYD3 by influencing the cellular redox state. The modulation of redox signaling by AMI-1 can lead to the activation of SMYD3, implicating redox-sensitive pathways or molecules in the regulation of SMYD3 activity and its downstream effects on epigenetic modifications and gene expression patterns. GSK-J1, a chemical activator, indirectly influences SMYD3 by targeting the H3K27 demethylase JMJD3. Inhibition of JMJD3 by GSK-J1 leads to increased H3K27 methylation, potentially activating SMYD3 and impacting the epigenetic landscape governed by SMYD3-mediated chromatin modifications.

ACY-241, NSC 207895, and RSL3 are activators that indirectly modulate SMYD3 activity by influencing the cellular redox state. The impact of these compounds on redox signaling can lead to the activation of SMYD3, implicating redox-sensitive pathways or molecules in the regulation of SMYD3 activity and its downstream effects on epigenetic modifications and gene expression patterns. SAH, a unique activator, directly activates SMYD3 by serving as a cofactor for its methyltransferase activity. SAH's role as a cofactor contributes to the regulation of SMYD3 activity, potentially influencing its methyltransferase function and the downstream cellular processes influenced by SMYD3-mediated chromatin modifications. These compounds can lead to the activation of SMYD3, potentially influencing its epigenetic functions and downstream cellular processes regulated by SMYD3-mediated chromatin modifications.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

GSK J1

1373422-53-7sc-391113
sc-391113A
10 mg
50 mg
$189.00
$797.00
(0)

GSK-J1 is a chemical activator that indirectly influences SMYD3 activity by targeting the H3K27 demethylase JMJD3. By inhibiting JMJD3, GSK-J1 leads to increased levels of H3K27 methylation, which is associated with transcriptional activation.

ACY-1215

1316214-52-4sc-507455
25 mg
$110.00
(0)

ACY-241 is a compound that indirectly activates SMYD3 by modulating the HDAC6 enzyme. Through its inhibitory action on HDAC6, ACY-241 can lead to alterations in histone acetylation patterns, potentially influencing the epigenetic modifications associated with SMYD3 activity.

NSC-207895

58131-57-0sc-364550
sc-364550A
5 mg
10 mg
$347.00
$653.00
(0)

NSC 207895 is a chemical activator that indirectly modulates SMYD3 activity by influencing the cellular redox state. Through its impact on redox signaling, NSC 207895 can lead to the activation of SMYD3.

RSL3

1219810-16-8sc-507385
10 mg
$250.00
(0)

RSL3 is a compound that indirectly activates SMYD3 by inducing ferroptosis, a form of regulated cell death. Ferroptosis involves the accumulation of lipid peroxides, and the induction of ferroptosis by RSL3 can lead to changes in the cellular environment that may influence SMYD3 activity.

Homocysteine

6027-13-0sc-507315
250 mg
$195.00
(0)

S-Adenosylhomocysteine (SAH) is a compound that directly activates SMYD3 by serving as a cofactor for its methyltransferase activity. SAH is a product of the methylation reactions catalyzed by methyltransferases, including SMYD3. Accumulation of SAH can act as a positive feedback signal, leading to the activation of SMYD3.

PARP Inhibitor VIII, PJ34

344458-15-7sc-204161
sc-204161A
1 mg
5 mg
$57.00
$139.00
20
(1)

PJ-34 is a compound that indirectly activates SMYD3 by affecting the poly(ADP-ribose) polymerase (PARP) pathway. Through its impact on PARP signaling, PJ-34 can lead to the activation of SMYD3, as PARP is implicated in regulating various cellular processes, including those influenced by SMYD3.

TBB

17374-26-4sc-202830
sc-202830A
sc-202830C
sc-202830B
sc-202830D
10 mg
25 mg
50 mg
100 mg
250 mg
$240.00
$363.00
$445.00
$760.00
$1781.00
17
(1)

4,5,6,7-Tetrabromobenzotriazole (TBB) is a chemical activator that indirectly modulates SMYD3 activity by affecting the CDK9/Cyclin T1 pathway. Through its impact on CDK9/Cyclin T1 signaling, TBB can lead to the activation of SMYD3, as CDK9 is implicated in regulating various cellular processes, including those influenced by SMYD3.