SMRT/SMRTe Activators

SMRT/SMRTe activators belong to a class of chemical compounds designed to selectively target and modulate the activity of the silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) and its related protein, SMRTe (SMRT family with ETO). These proteins are transcriptional corepressors that play a crucial role in the regulation of gene expression. SMRT and SMRTe are involved in transcriptional repression by recruiting histone deacetylases (HDACs) and other chromatin-modifying complexes to specific gene promoters. They act as transcriptional "brakes," inhibiting the transcriptional machinery from accessing and transcribing target genes.

Activation of SMRT and SMRTe by specific chemical compounds enhance their repressive functions, leading to the suppression of gene expression. These activators are designed to promote the recruitment of these corepressors to their target genes, thereby facilitating the repression of transcription and influencing various cellular processes. By modulating the activity of SMRT and SMRTe, researchers can gain insights into the complex regulatory networks that govern gene expression, chromatin remodeling, and cellular differentiation. These compounds serve as valuable tools for investigating the roles of SMRT and SMRTe in various cellular contexts and uncovering their contributions to normal cellular function.