SmcY Activators

The class of SmcY (KDM5D) activators comprises a range of compounds primarily influencing epigenetic regulation and chromatin remodeling, potentially modulating the activity of KDM5D, a key histone demethylase. This group includes DNA methyltransferase inhibitors like 5-Azacytidine and histone deacetylase inhibitors such as Trichostatin A and Sodium Butyrate. These compounds can lead to changes in chromatin structure, enhancing transcriptional activity and potentially upregulating KDM5D's role in epigenetic regulation.

Compounds like Retinoic Acid and Vitamin D3, known for their roles in modulating gene expression, are included for their potential impact on transcriptional processes that could influence KDM5D activity. Resveratrol, with its effects on metabolic pathways, and Curcumin, known for its broad effects on cellular signaling, could modulate KDM5D activity in processes related to aging, metabolism, and inflammation. Forskolin, by increasing cAMP levels, and antioxidants like Quercetin and Epigallocatechin Gallate (EGCG), might indirectly impact KDM5D activity by modulating transcription regulation and cellular stress response pathways. Additionally, compounds like Sulforaphane, known for influencing gene expression and cellular detoxification pathways, and Niacin, due to its role in cellular metabolism, are included for their potential indirect influence on KDM5D activity through metabolic pathways.