SMC1β Inhibitors
SMC1β inhibitors belong to a specialized class of chemical compounds that have garnered significant attention within the realm of molecular biology and cellular research. These inhibitors are designed to specifically target and modulate the activity of SMC1β, a crucial protein in the context of chromosomal dynamics and DNA repair mechanisms. SMC1β, short for Structural Maintenance of Chromosomes 1β, is a member of the Structural Maintenance of Chromosomes (SMC) protein family, which plays an integral role in the maintenance of genomic integrity and the organization of chromatin within the cell nucleus.
SMC1β is its involvement in the cohesin complex, a multiprotein assembly that plays a pivotal role in ensuring the accurate segregation of chromosomes during cell division. SMC1β, along with its partner SMC3, forms the core of the cohesin complex, which physically holds sister chromatids together until the appropriate moment of chromosome separation during mitosis and meiosis. By inhibiting SMC1β, researchers aim to disrupt this cohesin complex, potentially leading to aberrant chromosome segregation and genomic instability. This class of inhibitors offers a valuable tool for studying the fundamental processes of DNA replication, recombination, and repair, as it allows scientists to manipulate the delicate balance of cohesin complex dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AZD6482 | 1173900-33-8 | sc-364422 sc-364422A | 5 mg 10 mg | $275.00 $390.00 | 1 | |
Atrinib is a selective inhibitor of ATR kinase, which can impact the function of SMC1β by inhibiting the ATR-mediated phosphorylation of SMC1, a critical event for DNA damage response and cohesion establishment. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K and ATM kinases. By inhibiting ATM, it prevents the phosphorylation of SMC1, impacting the SMC1β function in DNA repair. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 is an ATM kinase inhibitor that can affect SMC1β function by blocking ATM-mediated phosphorylation required for SMC1β's role in chromosomal stability. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a DNA-PKcs inhibitor, which can influence SMC1β activity by inhibiting DNA repair pathways where SMC1β is a downstream effector. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $243.00 $1015.00 | 1 | |
KU-60019 is an improved analog of KU-55933, acting as an ATM inhibitor to prevent the phosphorylation of SMC1β, impacting its role in DNA damage response. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
AZD6738 is an inhibitor of ATR kinase, and thus affects SMC1β activity by preventing its activation through phosphorylation. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $104.00 | 8 | |
CGK733 is an inhibitor of ATM and ATR kinases, and it can affect SMC1β function by disrupting the phosphorylation signaling pathways necessary for its role in maintaining genomic stability. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
SCH900776 inhibits Chk1, a downstream effector kinase of ATR, and by doing so, it indirectly affects SMC1β function in the DNA damage response. | ||||||
JNK Inhibitor IX | 312917-14-9 | sc-202671 | 5 mg | $226.00 | 6 | |
B02 is a RAD51 inhibitor, which can influence SMC1β indirectly by affecting homologous recombination repair, a pathway where SMC1β may have a role. | ||||||