Sm E Activators
These compounds specifically activate Sm E by targeting the SF3B complex, a component of the spliceosome involved in mRNA splicing. By inhibiting the SF3B complex, these activators disrupt the normal splicing process, leading to the inclusion of specific exons and alternative splicing events. This enhanced splicing activity ultimately results in increased functional activity of Sm E protein. This disruption promotes the assembly of functional spliceosomes and enhances the efficiency of mRNA splicing, leading to increased functional activity of Sm E protein.
Other compounds, such as Spliceostatin A, E7107, and Meayamycin B, also target the SF3B complex, resulting in similar effects on pre-mRNA splicing and subsequent activation of Sm E protein. These compounds provide a unique and direct means of activating Sm E protein through the modulation of pre-mRNA splicing, highlighting the importance of alternative splicing regulation in the functional activity of this protein.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B is a natural product found in Streptomyces platensis. It inhibits the SF3B complex, a component of the spliceosome, leading to the disruption of pre-mRNA splicing. This disruption enhances the functional activity of Sm E protein by promoting the inclusion of specific exons and alternative splicing events. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a flavonoid compound found in the leaves of Ginkgo biloba. It inhibits the serine/arginine-rich protein kinase SRPK1, which phosphorylates SR proteins involved in spliceosome assembly. By inhibiting SRPK1, isoginkgetin enhances the functional activity of Sm E protein by promoting the assembly of functional spliceosomes and efficient mRNA splicing. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene is a natural product isolated from Streptomyces chromofuscus. It inhibits the SF3B complex, leading to the disruption of pre-mRNA splicing. This disruption enhances the functional activity of Sm E protein by promoting the inclusion of specific exons and alternative splicing events. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceostatin A is a natural product found in Pseudomonas bacteria. It inhibits the SF3B complex, leading to the disruption of pre-mRNA splicing. This disruption enhances the functional activity of Sm E protein by promoting the inclusion of specific exons and alternative splicing events. | ||||||
Platencin | 869898-86-2 | sc-202291 | 100 µg | $612.00 | ||
Platencin is a natural product found in Streptomyces platensis. It inhibits the SF3B complex, leading to the disruption of pre-mRNA splicing. This disruption enhances the functional activity of Sm E protein by promoting the inclusion of specific exons and alternative splicing events. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
FR901464 is a natural product found in Pseudomonas bacteria. It inhibits the SF3B complex, leading to the disruption of pre-mRNA splicing. This disruption enhances the functional activity of Sm E protein by promoting the inclusion of specific exons and alternative splicing events. | ||||||