SLUG Inhibitors
SLUG inhibitors are part of a specialized class of compounds designed to selectively target the SLUG protein, a transcription factor belonging to the Snail family of zinc finger proteins. SLUG, also known as Snail2, plays a significant role in regulating gene expression patterns involved in various cellular processes, including embryonic development, stem cell maintenance, and epithelial-mesenchymal transition (EMT). As a transcriptional regulator, SLUG controls the expression of genes responsible for cell adhesion molecules and other proteins crucial for cell migration and tissue remodeling. SLUG inhibitors are meticulously designed molecules engineered to interact with SLUG, aiming to disrupt its binding to DNA or modulate its role in transcriptional regulation.
Chemically, SLUG inhibitors are developed to selectively bind to specific regions or functional domains of the SLUG protein, interfering with its ability to bind to DNA sequences involved in gene regulation. The molecular structure of these inhibitors is intricately crafted to fit into the binding sites or active regions of SLUG, aiming to obstruct its function without significantly affecting other cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU is an agent known to affect various cellular pathways. In certain contexts, it may down-regulate SLUG expression, thereby impacting EMT. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, all trans can modulate cell differentiation processes. It might directly or indirectly down-regulate SLUG expression in specific cellular contexts. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to suppress SLUG expression in some cancer cell lines, inhibiting EMT and metastasis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate various cellular pathways. In certain conditions, it may down-regulate SLUG expression, affecting EMT. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, can affect DNA replication and transcription. It might down-regulate SLUG in specific conditions. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib targets the EGFR tyrosine kinase. EGFR signaling can regulate SLUG, and its inhibition might lead to SLUG down-regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, has been shown to suppress SLUG expression in certain cancer cell types. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant that can modulate redox-sensitive signaling pathways. In certain conditions, NAC might down-regulate SLUG expression. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide has been shown to inhibit the Wnt signaling pathway, which can regulate SLUG. Thus, it might down-regulate SLUG expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. Given that the PI3K/AKT pathway can influence SLUG expression, its inhibition might lead to SLUG down-regulation. | ||||||