Slp3 Inhibitors
Chemical inhibitors of Slp3 can be characterized by their ability to interrupt specific biochemical pathways that lead to the functional activity of Slp3. Staurosporine, a potent PKC inhibitor, would prevent the phosphorylation of Slp3 by inhibiting the kinase responsible for this process, thereby resulting in a decrease in Slp3 activity. Other chemicals like Bisindolylmaleimide I, Gö 6983, and Ro-31-8220 act as inhibitors of PKC. By blocking PKC activity, these compounds indirectly inhibit the phosphorylation and hence the functional inhibition of Slp3. For example, Gö 6976 targets specific PKC isoforms, alpha and beta, that are implicated in Slp3 regulation, and by inhibiting these isoforms, it constrains the phosphorylation and subsequent inhibition of Slp3.
Furthermore, ruboxistaurin and enzastaurin, as selective inhibitors of PKC beta, selectively prevent the phosphorylation of Slp3, thereby inhibiting its function. Sotrastaurin, which inhibits PKC, prevents the kinase from phosphorylating Slp3, leading to the inhibition of Slp3 activity. Chelerythrine also inhibits PKC, and as a result, it blocks the phosphorylation that would usually result in the inhibition of Slp3, thus maintaining the inhibition of Slp3 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent PKC inhibitor. By inhibiting PKC, staurosporine would prevent the phosphorylation and subsequent inhibition of Slp3, leading to a decrease in Slp3 activity indirectly through the PKC pathway. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This chemical is a specific inhibitor of PKC. By inhibiting PKC, Bisindolylmaleimide I would block the phosphorylation and thus the functional inhibition of Slp3 mediated by PKC. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor. Inhibition of PKC by Gö 6983 would lead to reduced phosphorylation of Slp3, thereby inhibiting its function. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
As a PKC inhibitor, Ro-31-8220 would suppress the activity of PKC, which is required for the phosphorylation-based inhibition of Slp3. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
This chemical selectively inhibits PKC alpha and beta, which are involved in the regulation of Slp3 activity. By inhibiting these PKC isoforms, Gö 6976 would hinder the phosphorylation and thus the functional inhibition of Slp3. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Ruboxistaurin is a selective inhibitor of PKC beta. Inhibition of PKC beta by ruboxistaurin would prevent the phosphorylation and subsequent functional inhibition of Slp3. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin inhibits PKC, and through this inhibition, it would prevent PKC from phosphorylating Slp3, resulting in the functional inhibition of Slp3 activity. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $254.00 $600.00 $1687.00 | 3 | |
Enzastaurin inhibits PKC beta, which is involved in phosphorylating Slp3. By inhibiting this kinase, enzastaurin would prevent the functional inhibition of Slp3. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a PKC inhibitor. By inhibiting PKC, chelerythrine would block the phosphorylation and subsequent inhibition of Slp3, thereby inhibiting Slp3 activity. | ||||||