SLC35D1 Activators
SLC35D1 activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of SLC35D1 by modulating various cellular signaling pathways and metabolic states. Resveratrol, Piceatannol, Quercetin, and Oleuropein all function primarily as activators of SIRT1, a deacetylase that enhances the cellular conditions for SLC35D1's nucleotide sugar transport, facilitating the efficiency of UDP-galactose transport into the Golgi apparatus for glycosylation. Similarly, Nicotinamide mononucleotide (NMN) elevates NAD+ levels, which in turn activates SIRT1, thereby potentially optimizing SLC35D1-mediated transport processes. Compounds that activate AMP-activated protein kinase (AMPK) such as Metformin, Berberine, Curcumin, Epigallocatechin gallate (EGCG), Silymarin, and Alpha-lipoic acid indirectly promote an energy-efficient cellular state, which is hypothesized to upregulate the transport efficiency of SLC35D1, a crucial component for the glycosylation of proteins. These activators, through their interaction with AMPK, may enhance the glycosylation substrate transport capacity of SLC35D1, thereby indirectly increasing its functional activity.
Spermidine, while known for its role in autophagy, may also contribute to the maintenance or enhancement of SLC35D1 activity by ensuring the proper turnover and functionality of nucleotide sugar transporters within the Golgi. The orchestrated actions of these chemical activators create a cellular milieu that favors the transport tasks undertaken by SLC35D1, without directly upregulating its expression or acting as direct ligands for the transporter. Instead, their influence on SIRT1 and AMPK signaling pathways and autophagic processes converge to maintain and potentially enhance the function of SLC35D1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol enhances SLC35D1 activity by activating SIRT1, which deacetylates proteins involved in the nucleotide sugar transport process that SLC35D1 mediates. Increased SIRT1 activity can lead to improved efficiency of SLC35D1's role in transporting UDP-galactose into the Golgi apparatus for glycosylation processes. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol, a hydroxylated analog of resveratrol, activates SIRT1 similarly to resveratrol. Through SIRT1 activation, Piceatannol can enhance the function of SLC35D1 by promoting a more favorable environment for its nucleotide sugar transport activity, thus supporting glycosylation pathways in which SLC35D1 is essential. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to increase the activity of SIRT1. By activating SIRT1, Quercetin can indirectly enhance SLC35D1 activity by creating conditions that favor the transport of UDP-galactose, a substrate of SLC35D1, into the Golgi for use in glycosylation. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor to NAD+ which is a substrate for SIRT1, thereby enhancing SLC35D1 activity indirectly through SIRT1 activation. Elevated NAD+ levels contribute to the deacetylation of proteins that are part of the nucleotide sugar transport chain, possibly optimizing SLC35D1-mediated transport processes. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMP-activated protein kinase (AMPK) which can influence cellular metabolism and thereby indirectly enhance the activity of transporters such as SLC35D1. AMPK activation can lead to cellular states that favor energy efficiency, potentially upregulating the transport efficiency of SLC35D1 for glycosylation substrates. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPK, similarly to metformin. Through this activation, it might enhance the activity of SLC35D1 by promoting a cellular environment that requires efficient UDP-galactose transport for glycosylation, leveraging SLC35D1's role in these processes. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to stimulate autophagy and may enhance the recycling of cellular components, including the turnover of nucleotide sugar transporters like SLC35D1. This could indirectly maintain or enhance the functional activity of SLC35D1 by ensuring its presence and functionality within the Golgi apparatus. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to activate AMPK. The activation of AMPK by Curcumin may enhance SLC35D1 function by promoting cellular states that favor energy conservation and efficiency, potentially leading to increased UDP-galactose transport activity of SLC35D1 as part of the adaptive response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to influence the activity of various kinases and has been shown to activate AMPK. This activation could indirectly enhance SLC35D1 activity by promoting cellular energy efficiency, which may be beneficial for the activity of nucleotide sugar transporters such as SLC35D1. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $359.00 $530.00 $791.00 $6773.00 | 2 | |
Oleuropein enhances the activity of SIRT1, which could indirectly lead to the enhanced function of SLC35D1 by modulating the deacetylation status of proteins involved in nucleotide sugar transport, thereby potentially improving the transport efficiency of SLC35D1 within the Golgi apparatus. | ||||||