Slc22a27 Activators

Chemical activators of solute carrier family 22, member 27 include a range of substrates that interact with the transporter, leading to its functional activation. Estrone sulfate, dehydroepiandrosterone sulfate, and pregnenolone sulfate are endogenous compounds that bind to this transporter, facilitating their own translocation across cellular membranes and thus activating the protein's transport capabilities. Similarly, the transporter is activated by the presence of corticosterone and benzylpenicillin, which are recognized as substrates and are moved across the cell membrane by the protein. Prostaglandin E2 enhances the transport function of solute carrier family 22, member 27, likely by interacting with the transporter to facilitate the uptake of other substrates. The activation of the transporter by estradiol 17-beta-D-glucuronide and indoxyl sulfate follows a comparable mechanism, wherein these substrates are actively translocated by the transporter, thereby increasing its activity.

Furthermore, compounds like taurocholate and p-Aminohippurate also serve as substrates, their transport by solute carrier family 22, member 27 effectively increases the protein's activity by engaging its substrate transport function. Probenecid acts as an activator by competitively inhibiting the transport of other substrates, which may result in a selective enhancement of the transporter's activity for specific substrates. Ouabain, while not a direct substrate, can increase the electrochemical gradient across cell membranes, a condition that solute carrier family 22, member 27 relies on for the efficient uptake of its substrates, thereby indirectly enhancing its transport function. Collectively, these chemicals activate solute carrier family 22, member 27 by either serving as substrates themselves or by modulating the cellular conditions to favor the transport activity of the protein.