Skint11 Inhibitors
Skint11 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of Skint11, a protein that belongs to the *Skint* family of immunoglobulin-like proteins. These proteins are primarily expressed in epithelial tissues and are known for their involvement in modulating immune cell interactions, particularly with γδ T cells, which play a critical role in epithelial defense and tissue maintenance. While the exact biological function of Skint11 is not fully understood, it is believed to contribute to immune signaling pathways that regulate immune cell activation, development, and communication within the epithelial environment. Inhibitors of Skint11 are crafted to bind to key regions of the protein, interfering with its interactions with immune cells or other signaling molecules, thereby disrupting its role in maintaining immune homeostasis at epithelial surfaces.
The development of Skint11 inhibitors involves an in-depth understanding of the protein's structural and functional characteristics. Researchers utilize techniques such as molecular docking, X-ray crystallography, and computational modeling to identify specific binding sites or functional domains on Skint11 that are essential for its interactions. These inhibitors are typically small molecules designed to fit precisely within these sites, blocking the protein's activity without affecting other members of the Skint family. Once synthesized, these inhibitors undergo rigorous biochemical assays to assess their binding affinity, specificity, and ability to inhibit Skint11-mediated processes. Through the use of Skint11 inhibitors, researchers are able to explore the biological roles of this protein in more detail, providing insights into how it modulates immune responses and maintains epithelial integrity. By studying the effects of inhibiting Skint11, scientists gain a better understanding of the complex interplay between epithelial tissues and immune cells, further elucidating the importance of the *Skint* family in regulating these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits calcineurin, which is involved in the activation of T cells, leading to inhibition of transcription factors necessary for T cell differentiation and function, thus indirectly inhibiting the selection and upkeep of intraepithelial T cells 11 by reducing T cell activity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Binds to FKBP12, forming a complex that inhibits calcineurin, thereby inhibiting the activation of nuclear factors in T cells, such as NFAT, leading to decreased T cell responses and indirectly affecting the function of selection and upkeep of intraepithelial T cells 11. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to FKBP12 and inhibits mTOR pathway, which is crucial for T cell proliferation and survival, thereby indirectly inhibiting the selection and upkeep of intraepithelial T cells 11 by limiting T cell proliferation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Acts as an agonist on sphingosine-1-phosphate receptors which are involved in the egress of T cells from lymphoid organs; by influencing this pathway, T cell trafficking is altered, which can indirectly inhibit the function of selection and upkeep of intraepithelial T cells 11. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A glucocorticoid that inhibits NF-κB signaling, reducing cytokine production and T cell activation; this indirect action can decrease T cell-mediated immune responses, thereby inhibiting the function of selection and upkeep of intraepithelial T cells 11. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
Inhibits inosine monophosphate dehydrogenase, leading to a depletion of guanosine nucleotides which are necessary for T cell and B cell proliferation, indirectly inhibiting the function of selection and upkeep of intraepithelial T cells 11 by impeding T cell proliferation. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $36.00 $173.00 $316.00 | ||
Inhibits calcineurin similarly to FK506 and Cyclosporin A, thereby inhibiting T cell activation and indirectly affecting the selection and upkeep of intraepithelial T cells 11 by reducing T cell-mediated immunity. | ||||||
Fingolimod | 162359-55-9 | sc-507334 | 10 mg | $160.00 | ||
Functions as a sphingosine-1-phosphate receptor modulator, trapping T cells in lymph nodes and preventing their circulation which can indirectly inhibit the function of selection and upkeep of intraepithelial T cells 11 by reducing their presence at epithelial sites. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Inhibits the N-WASP-ARP2/3 complex, which is critical for actin polymerization and thus T cell receptor signaling; this can indirectly inhibit the function of selection and upkeep of intraepithelial T cells 11 by impairing T cell receptor-mediated activation. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Inhibits thioredoxin reductase, altering redox balance within T cells, which can disrupt T cell receptor signaling and thus indirectly inhibit the function of selection and upkeep of intraepithelial T cells 11. | ||||||