Siglec-1 Activators
Siglec-1 activators comprise a diverse group of chemicals that either directly engage Siglec-1 or indirectly modulate its activity by influencing cellular processes involved in immune responses. Cholesterol promotes Siglec-1 activation by enhancing lipid raft formation, facilitating receptor-ligand interactions critical for immune modulation. Sialic acid, acting as a direct ligand, triggers Siglec-1 activation, initiating downstream signaling events that regulate immune responses and cellular interactions. Mannose and N-Acetylglucosamine serve as ligands for Siglec-1, directly activating the receptor and modulating immune-related signaling pathways. Dextran sulfate mimics sialylated ligands, activating Siglec-1 and influencing immune-related processes. Lipopolysaccharide (LPS) indirectly activates Siglec-1 by initiating immune responses through Toll-like receptors, impacting Siglec-1 expression and function.
Ceramide influences Siglec-1 by modulating membrane microdomains, affecting receptor organization and ligand interactions. Fucoidan, resembling sialic acid-containing molecules, binds to Siglec-1, leading to receptor activation and modulation of immune-related signaling pathways. Trehalose 6,6'-dimycolate and β-Glucans indirectly activate Siglec-1 by engaging with receptors and influencing Siglec-1 expression and function in immune responses. Fucose serves as a ligand, directly activating Siglec-1 and initiating downstream signaling events involved in immune regulation. Polymyxin B indirectly modulates Siglec-1 by engaging with Toll-like receptors, impacting Siglec-1 expression and function in immune responses. These diverse Siglec-1 activators showcase the receptor's involvement in immune modulation and cellular recognition processes, emphasizing the intricate network of interactions and signaling pathways that contribute to Siglec-1 activation and its role in immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol activates Siglec-1 by promoting lipid raft formation. Cholesterol enhances the clustering of Siglec-1 on the cell membrane, facilitating its interaction with sialylated ligands and modulating downstream signaling pathways involved in immune responses. | ||||||
N-Acetylneuraminic acid | 131-48-6 | sc-281055A sc-281055 sc-281055D sc-281055B sc-281055C | 1 g 5 g 25 g 100 g 250 g | $84.00 $156.00 $326.00 $572.00 $1363.00 | ||
N-Acetylneuraminic acid activates Siglec-1 by serving as a ligand for the receptor. The binding of N-Acetylneuraminic acid to Siglec-1 triggers receptor activation, leading to downstream signaling events involved in the regulation of immune responses and cellular interactions. | ||||||
D-Mannose | 3458-28-4 | sc-211180 sc-211180A | 100 g 250 g | $103.00 $161.00 | 1 | |
Mannose activates Siglec-1 by acting as a ligand that binds to the receptor. This interaction induces conformational changes in Siglec-1, initiating downstream signaling pathways involved in immune modulation and cellular recognition processes. | ||||||
Dextran Sulfate, Sodium Salt MW ~500,000 | 9011-18-1 | sc-203917 sc-203917A sc-203917B sc-203917C | 10 g 50 g 100 g 1 kg | $57.00 $166.00 $374.00 $3131.00 | 7 | |
Dextran sulfate activates Siglec-1 by mimicking sialylated ligands. The structural similarity of dextran sulfate to sialic acid-containing molecules allows it to interact with Siglec-1, leading to receptor activation and modulation of immune-related signaling pathways. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Lipopolysaccharide (LPS) indirectly activates Siglec-1 by inducing immune responses. LPS engages with Toll-like receptors, initiating downstream signaling cascades that can influence Siglec-1 expression and function, thereby modulating immune reactions and cellular responses. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide activates Siglec-1 by modulating lipid composition. Ceramide influences membrane microdomains, affecting the organization of Siglec-1 on the cell surface and facilitating its interaction with ligands, resulting in the modulation of immune responses. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $94.00 $162.00 $306.00 | 1 | |
N-Acetylglucosamine activates Siglec-1 by serving as a ligand for the receptor. The binding of N-Acetylglucosamine to Siglec-1 initiates receptor activation and downstream signaling pathways, contributing to the regulation of immune responses and cellular recognition. | ||||||
Fucoidan | 9072-19-9 | sc-255187 sc-255187A | 5 g 10 g | $190.00 $318.00 | 7 | |
Fucoidan activates Siglec-1 by interacting with sialylated ligands. Fucoidan, resembling the structure of sialic acid-containing molecules, binds to Siglec-1, leading to receptor activation and modulation of downstream signaling pathways involved in immune responses. | ||||||
b-Glucan, Saccharomyces cerevisiae | 9012-72-0 | sc-203832 | 25 mg | $307.00 | ||
β-Glucans activate Siglec-1 by modulating immune responses. These polysaccharides engage with receptors, initiating signaling cascades that can influence Siglec-1 expression and function, thereby modulating immune reactions and cellular recognition processes. | ||||||
L-(−)-Fucose | 2438-80-4 | sc-221792 sc-221792A sc-221792B sc-221792C | 10 mg 5 g 50 g 100 g | $31.00 $153.00 $454.00 $840.00 | ||
Fucose activates Siglec-1 by serving as a ligand for the receptor. The binding of fucose to Siglec-1 triggers receptor activation, leading to downstream signaling events involved in the regulation of immune responses and cellular interactions. | ||||||