Chemical inhibitors of SFT2D2 can influence the protein's function through various molecular mechanisms. Staurosporine serves as a broad-spectrum protein kinase inhibitor, which can inhibit the activity of kinases that would otherwise phosphorylate SFT2D2, directly leading to its inhibition. Similarly, PP2 targets the Src family of tyrosine kinases, potentially ceasing phosphorylation events essential for SFT2D2's function. Inhibition of these kinases disrupts the phosphorylation-dependent regulation mechanisms that are crucial for SFT2D2 activity. The PI3K inhibitors LY294002 and Wortmannin can disrupt the phosphoinositide signaling pathways that are potentially involved in SFT2D2 regulation. By curbing PI3K activity, these inhibitors may enforce an inhibitory effect on the downstream signaling that would otherwise modulate SFT2D2's activity, leading to a functional inhibition of the protein.
In addition to PI3K, SFT2D2 can be inhibited by interference with the MEK/ERK pathway. U0126, PD98059, and SL327 are selective inhibitors of MEK1/2 which, by inhibiting MEK, can impede the upstream signaling required for the proper functioning of SFT2D2. The inhibition of MEK prevents the subsequent activation of ERK, a kinase that may be involved in the regulation of SFT2D2, thus leading to its functional inhibition. The mTOR inhibitor Rapamycin can inhibit SFT2D2 by blocking the mTOR pathway, which is a critical regulator of cellular metabolism and growth signals that may intersect with SFT2D2's functional pathway. Additionally, GF109203X inhibits protein kinase C, which is likely involved in pathways that regulate SFT2D2, and ZM336372 targets Raf kinase, further disrupting potential regulatory kinase signaling affecting SFT2D2 activity. Lastly, SP600125 inhibits the JNK pathway, which may regulate SFT2D2, thus providing functional inhibition by disrupting necessary phosphorylation events that SFT2D2 might rely on for its activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad range of protein kinases which could lead to the inhibition of kinases that phosphorylate SFT2D2, thereby inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, which may be involved in intracellular signaling pathways that regulate the activity of SFT2D2, leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, which can disrupt the phosphoinositide signaling potentially involved in the control of SFT2D2, causing functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, which is upstream of ERK that might be involved in the signaling regulating SFT2D2, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAP kinase, which if involved in the signaling pathways regulating SFT2D2, would result in functional inhibition of SFT2D2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which might be involved in pathways regulating SFT2D2 leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which could be part of the signaling pathways that regulate SFT2D2 and thus inhibit its function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a protein kinase C inhibitor which could inhibit signaling pathways involving PKC that regulate the activity of SFT2D2, thus inhibiting its function. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 inhibits MEK, which could be involved in the signaling pathways that regulate SFT2D2, leading to functional inhibition of SFT2D2. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Src family tyrosine kinases which could lead to the inhibition of kinases that phosphorylate SFT2D2, thereby directly inhibiting its function. | ||||||