SETX Activators
SETX activators, referring to compounds that activate the Sirtuin 1 (SIRT1) enzyme, are a diverse group of molecules that engage with this NAD+-dependent deacetylase. The sirtuin family, to which SIRT1 belongs, is implicated in various cellular processes including aging, transcription, apoptosis, inflammation, and stress resistance through their role in deacetylating both histone and non-histone proteins. SETX activators are not a homogenous chemical class, but rather a collection of structurally diverse compounds united by their functional ability to enhance the activity of SIRT1. The structural diversity among these activators is vast, ranging from natural polyphenolic compounds, like resveratrol found in red wine, to flavonoids such as quercetin and fisetin, to synthetic small molecules like the SRT series. This diversity underscores the complex interaction landscape that these molecules have with the SIRT1 enzyme and possibly other cellular targets.
The interaction between SETX activators and SIRT1 is intricate and can involve direct binding to the enzyme, allosteric modulation, or indirect effects that lead to enhanced SIRT1 activity. For example, some SETX activators may bind to a specific domain on the SIRT1 enzyme, inducing a conformational change that increases its catalytic efficiency. Others might increase the local concentration of NAD+, the essential cofactor for SIRT1, thus indirectly enhancing its activity. The structural variability among SETX activators is mirrored in their mechanisms of action; while some may interact directly with the enzyme's active site, others may bind to distinct allosteric sites or even affect SIRT1 expression at the transcriptional level. This functional diversity is reflected in the wide range of chemical structures that qualify as SETX activators, from simple flavonoids to complex synthetic molecules, each engaging with the SIRT1 enzyme in a unique manner.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol found in various plants, is known for its involvement in the SIRT1/AMPK pathway. By activating SIRT1, it deacetylates and activates SETX, promoting DNA damage repair and preventing cellular stress-induced SETX inactivation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, plays a role in SETX activation through its interaction with the PI3K/Akt pathway. By inhibiting PI3K, quercetin indirectly enhances SETX activity, as activated Akt has been linked to SETX inhibition. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, found in various plants, modulates the MAPK pathway. Through its influence on this pathway, it indirectly supports SETX activation by regulating downstream factors that impact SETX function and DNA damage response. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $143.00 $571.00 $6125.00 | 4 | |
Lycopene, a carotenoid found in tomatoes, influences the NF-κB pathway. Its inhibition of NF-κB activation indirectly activates SETX by preventing NF-κB-mediated downregulation of SETX expression, ensuring its availability for DNA repair processes. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid, a pentacyclic triterpenoid, affects the JNK pathway. Through its modulation of JNK signaling, it indirectly supports SETX activation by preventing JNK-mediated phosphorylation and subsequent degradation of SETX. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine, an alkaloid from black pepper, influences the Wnt/β-catenin pathway. By inhibiting Wnt signaling, it indirectly activates SETX, as the Wnt pathway has been implicated in SETX regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, impacts the ERK/MAPK pathway. Its inhibition of ERK signaling indirectly activates SETX by preventing ERK-mediated phosphorylation, which is associated with SETX inactivation. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein, a flavonoid, modulates the Nrf2/ARE pathway. Its activation of Nrf2 indirectly supports SETX activation by enhancing the cellular antioxidant response, reducing oxidative stress, and promoting an environment conducive to SETX function. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol, a triterpenoid, influences the HSP90 pathway. By inhibiting HSP90, it indirectly activates SETX, as HSP90 is involved in SETX stability and function. Celastrol-mediated disruption of HSP90-SETX interaction promotes SETX activity in DNA repair processes. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin, a flavone, interacts with the PI3K/Akt/mTOR pathway. Its inhibition of this pathway indirectly supports SETX activation by preventing Akt-mediated phosphorylation and subsequent degradation of SETX, ensuring its availability for DNA repair. | ||||||