SERTAD4 Activators
SERTAD4 activators are a diverse array of chemical compounds that indirectly promote the functional activity of SERTAD4 through a multitude of intracellular signaling mechanisms. Forskolin, Rolipram, and IBMX elevate intracellular cAMP and subsequently activate PKA, which is likely to phosphorylate and activate transcription factors that elevate the transcription and function of SERTAD4. Similarly, Epigallocatechin gallate, by inhibiting competing protein kinases, and Sphingosine-1-phosphate, through activation of sphingosine-1-phosphate receptors, can initiate signaling cascades that result in the phosphorylation of molecules involved in SERTAD4 regulation. Retinoic Acid and Lithium Chloride, by engaging with nuclear receptors and the GSK-3 signaling pathway respectively, may lead to transcriptional changes that enhance the activity of SERTAD4. Moreover, the actions of Trichostatin A and 5-Azacytidine in altering chromatin structure and DNA methylation patterns could result in increased transcription of genes whose products are necessary for the proper functioning of SERTAD4.
Curcumin's broad range of influence on signaling pathways could also lead to an enhancement of SERTAD4 activity by upregulating transcription factors that interact with or regulate SERTAD4. Additionally, the direct activation of PKC by PMA may result in the phosphorylation of proteins that are essential for the activation of SERT.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate transcription factors that increase the expression and functional activity of SERTAD4. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown, which leads to an increase in PKA activity and downstream enhancement of SERTAD4 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in the cell, thereby enhancing PKA and PKG activity which can indirectly increase SERTAD4 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound inhibits several protein kinases, potentially altering signaling pathways that augment the functional activity of SERTAD4 by reducing competitive signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
It acts on its receptors to activate intracellular signaling pathways, including PI3K/Akt, potentially enhancing the activity of SERTAD4 through post-translational modifications. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences gene expression through its receptors, which may lead to an upregulation of SERTAD4 activity by enhancing the transcription of genes that encode for proteins that interact with or modulate SERTAD4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium acts on the GSK-3 signaling pathway, leading to increased nuclear beta-catenin levels, which may upregulate SERTAD4 activity through transcriptional regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor can lead to changes in chromatin structure, potentially enhancing the transcription of genes that upregulate the functional activity of SERTAD4. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can lead to the demethylation and subsequent activation of genes that may be involved in pathways that enhance SERTAD4 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate numerous signaling pathways, potentially leading to the upregulation of transcription factors that enhance SERTAD4 activity. | ||||||