Septin 12 Inhibitors
Septin 12 inhibitors represent a class of chemical compounds designed to interfere with the activity of septin 12, a critical protein within the septin family. Septins are a group of cytoskeletal GTP-binding proteins that play essential roles in cellular processes, such as cytokinesis, membrane dynamics, and cellular morphogenesis. Septin 12, specifically, has been identified as a crucial component of the septin filaments involved in maintaining cellular architecture and regulating membrane organization. These inhibitors are primarily developed for research purposes, allowing scientists to investigate the functional roles of septin 12 in various cellular processes.
The mechanism of action of septin 12 inhibitors often involves disrupting the normal assembly or organization of septin filaments. Many of these compounds target cellular components like microtubules and actin filaments, which are closely associated with septin organization. For example, inhibitors like Nocodazole and Vinblastine destabilize microtubules, which in turn affects septin filamentation. Similarly, compounds like Latrunculin A and Cytochalasin D disrupt actin polymerization, leading to alterations in septin assembly. By interfering with these cytoskeletal elements, septin 12 inhibitors provide researchers with valuable tools to investigate the intricate roles of septin proteins in cellular processes, including cell division, migration, and membrane compartmentalization. Overall, these inhibitors serve as indispensable assets in the realm of cell biology research, shedding light on the complexities of septin-mediated cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forchlorfenuron | 68157-60-8 | sc-204759 sc-204759A | 500 mg 1 g | $112.00 $181.00 | 2 | |
Forchlorfenuron inhibits Septin 12 by directly interfering with microtubule dynamics, hindering the proper formation and stabilization of Septin 12 filaments, crucial for cellular architecture and function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin polymerization, leading to a consequential impairment in Septin 12 organization and assembly by destabilizing the actin cytoskeleton, which is fundamental to Septin's structural support. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole exerts its inhibitory effect on Septin 12 by destabilizing microtubules, which plays a pivotal role in maintaining Septin filament organization, thereby affecting cellular division and integrity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D alters actin dynamics, leading to the disruption of Septin 12 assembly by preventing the formation of actin filaments, crucial for the proper localization and function of Septin proteins. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization and thus interfering with Septin 12 polymerization processes, which are essential for the maintenance of cellular structure and division. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly, directly affecting Septin 12 organization by inhibiting the proper formation of microtubules necessary for the structural stability and distribution of Septin filaments. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 inhibits actin polymerization, impairing Septin assembly by preventing the formation of actin filaments, thereby destabilizing the cytoskeletal framework essential for Septin function. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Latrunculin B disrupts actin filaments, leading to a direct impact on Septin 12 localization and function by destabilizing the actin cytoskeleton, which is vital for the organization of Septin proteins. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, impacting actin and Septin dynamics by preventing myosin's interaction with actin filaments, crucial for the maintenance of cellular structure and Septin organization. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $42.00 $78.00 $161.00 $286.00 | ||
2,3-Butanedione monoxime inhibits the actin-myosin interaction, affecting Septin 12 assembly by disrupting the contractile machinery of the cell, essential for the dynamics and stability of Septin filaments. | ||||||