Semaphorin Inhibitors
Semaphorin inhibitors are chemical compounds that function by modulating or blocking the activity of semaphorins, a large family of proteins known for their role in cell signaling, particularly in processes involving cellular migration, axonal guidance, and the regulation of cellular architecture. Semaphorins, initially identified in the nervous system, play a pivotal role in the development and maintenance of various tissues by acting as cues that guide cellular movement and pattern formation. These proteins bind to their receptors, primarily plexins and neuropilins, to initiate downstream signaling cascades that influence cellular motility, adhesion, and cytoskeletal dynamics. Inhibition of semaphorin activity can interfere with these signaling pathways, leading to alterations in cellular behavior, such as changes in migration patterns or the restructuring of cellular frameworks.
At the molecular level, semaphorin inhibitors can affect the interaction between semaphorins and their receptors or disrupt downstream signaling pathways triggered by semaphorin-receptor binding. These inhibitors can be designed to target specific semaphorin-receptor interactions, thereby providing a means to modulate specific signaling outcomes. For instance, semaphorin inhibitors may block the ability of semaphorins to activate plexin-mediated Rho GTPase signaling pathways, which are crucial for regulating cytoskeletal rearrangements and cellular morphology. Additionally, inhibiting semaphorin function can have broader implications in the regulation of cell-to-cell communication, extracellular matrix interactions, and even the modulation of vascular and immune systems, as semaphorins are known to influence a wide array of biological processes beyond neural development. The selective inhibition of semaphorin signaling thus offers a sophisticated tool for studying the intricate network of signals that govern cellular architecture and migration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine may downregulate Semaphorin by directly inhibiting the Hedgehog signaling pathway components, potentially leading to decreased transcription of genes under this pathway's control. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could decrease Semaphorin expression by directly inhibiting PI3K, leading to reduced activation of AKT and subsequent transcriptional repression of growth-related genes, including those for Semaphorin. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By specifically inhibiting mTOR, Rapamycin might reduce the mRNA translation rate of Semaphorin by impairing the assembly of the eukaryotic initiation factor complex. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 could decrease Semaphorin expression by selectively inhibiting MEK1, thereby reducing ERK pathway signaling and diminishing transcriptional activation of associated genes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 may lead to a decrease in Semaphorin expression by selectively inhibiting p38 MAPK, resulting in a reduction of downstream target gene transcription, including genes involved in cell differentiation and apoptosis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
This compound could inhibit Semaphorin expression by specifically inhibiting JNK, thereby reducing the transcription of stress response genes, some of which may be upstream regulators of Semaphorin. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 may reduce Semaphorin levels by inhibiting ROCK, which could lead to alterations in actin cytoskeleton organization and subsequently lower the expression of genes involved in neuronal guidance. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could reduce Semaphorin expression by inhibiting histone deacetylases, leading to alterations in gene expression profiles due to changes in chromatin structure and histone acetylation status. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine may decrease Semaphorin expression by promoting the demethylation of gene promoter regions, which could lead to the suppression of gene activity. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
By inhibiting the production of Wnt proteins, Wnt-C59 could lead to a decrease in the transcriptional activity of Wnt/β-catenin target genes, potentially including those for Semaphorin. | ||||||