Date published: 2025-10-25

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Sel-1L2 Inhibitors

Sel-1L2 inhibitors belong to a specialized class of chemical compounds designed to selectively target and modulate the activity of the Sel-1L2 protein. The Sel-1L2 protein, a member of the Sel-1 family, plays a pivotal role in cellular processes related to protein quality control and degradation. This class of inhibitors is meticulously designed to interfere with the function of Sel-1L2, thereby influencing the intricate cellular pathways associated with protein homeostasis. By selectively inhibiting Sel-1L2, these compounds exert their effects on cellular mechanisms responsible for the recognition, sorting, and eventual disposal of misfolded or aberrant proteins within the cell.Sel-1L2 inhibitors is crafted to interact specifically with the active sites or binding pockets of the Sel-1L2 protein, disrupting its normal function. The goal is to modulate the intricate balance between protein synthesis and degradation, thereby influencing cellular proteostasis.

Researchers and developers are keenly interested in understanding the structural nuances of Sel-1L2 inhibitors to enhance their selectivity and efficacy. As these inhibitors undergo further studies, the intricate details of their interaction with Sel-1L2 at the molecular level become critical for elucidating their potential impact on cellular protein quality control pathways. The ongoing exploration of Sel-1L2 inhibitors contributes significantly to our understanding of cellular biology and opens avenues for targeted interventions in conditions associated with protein misfolding and degradation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG-132 [Z-Leu- Leu-Leu-CHO] is a proteasome inhibitor that may impact the ERAD pathway, potentially affecting Sel-1L2-associated protein degradation processes.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib, a proteasome inhibitor, could influence Sel-1L2 function by altering the degradation of misfolded proteins in the ER.

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$112.00
$199.00
$347.00
$683.00
$1336.00
$5722.00
12
(1)

Eeyarestatin I inhibits ERAD by disrupting p97/VCP function, which is vital for the extraction of misfolded proteins, potentially impacting Sel-1L2 roles.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$169.00
$299.00
66
(3)

Tunicamycin inhibits N-linked glycosylation, stressing the ER and potentially affecting Sel-1L2's role in protein quality control.

Kifunensine

109944-15-2sc-201364
sc-201364A
sc-201364B
sc-201364C
1 mg
5 mg
10 mg
100 mg
$132.00
$529.00
$1005.00
$6125.00
25
(2)

Kifunensine is a mannosidase inhibitor that interferes with ER-associated glycoprotein degradation, potentially influencing Sel-1L2-mediated pathways.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine, known for affecting lysosomal function, can indirectly impact the cellular degradation pathways associated with Sel-1L2.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Clasto-Lactacystin β-lactone specifically targets the proteasome, potentially influencing Sel-1L2-associated degradation processes.

Radicicol

12772-57-5sc-200620
sc-200620A
1 mg
5 mg
$90.00
$326.00
13
(1)

Radicicol binds to Hsp90, potentially affecting its client proteins, including those involved in ERAD pathways linked to Sel-1L2.

17-AAG

75747-14-7sc-200641
sc-200641A
1 mg
5 mg
$66.00
$153.00
16
(2)

17-AAG is an Hsp90 inhibitor, which might impact the processing and degradation of proteins in pathways involving Sel-1L2.

Guanabenz HCl

23113-43-1sc-507500
100 mg
$241.00
(0)

Guanabenz has been shown to modulate ER stress responses, potentially affecting Sel-1L2-related pathways in protein quality control.