ERα (D-12): sc-8005. Western blot analysis of ERα expression in untreated (A) and Radicicol (sc-200620) treated (B) MCF7 whole cell lysates. Note down regulation of ERα expression in lane B.
Radicicol (CAS 12772-57-5)
See product citations (13)
Alternate Names:
Monorden
Application:
Radicicol is a potent inhibitor of HSP 90, SRC, and Cox-2
CAS Number:
12772-57-5
Purity:
≥97%
Molecular Weight:
364.78
Molecular Formula:
C18H17ClO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Radicicol is a compound belongs to the ansamycin family—a group of products widely utilized in scientific disciplines. Offering a broad spectrum of applications, radicicol has been studied extensively in the context of bacterial infections. Radicicol operates by impeding protein synthesis in bacteria, making it effective as a bacteriostatic agent. This inhibitory effect arises from radicicol′s ability to bind to ribosomes—cellular structures responsible for protein production. Once bound, radicicol obstructs the ribosomes′ protein synthesis machinery, ultimately leading to bacterial death.
Radicicol (CAS 12772-57-5) References
- Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol. | Kwon, HJ., et al. 1992. Cancer Res. 52: 6926-30. PMID: 1458481
- Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site. | Hadden, MK., et al. 2006. Curr Top Med Chem. 6: 1173-82. PMID: 16842154
- Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells. | Youn, CK., et al. 2013. Korean J Physiol Pharmacol. 17: 315-20. PMID: 23946691
- Radicicol induces intracellular accumulation of glycan-deficient clusterin variant. | Choi, I., et al. 2015. Biochem Biophys Res Commun. 458: 555-560. PMID: 25680466
- Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway. | Ji, J., et al. 2018. Aging Cell. 17: e12774. PMID: 29740932
- Identification of Natural Compound Radicicol as a Potent FTO Inhibitor. | Wang, R., et al. 2018. Mol Pharm. 15: 4092-4098. PMID: 30063141
- Radicicol rescues yeast cell death triggered by expression of human α-synuclein and its A53T mutant, but not by human βA4 peptide and proapoptotic protein bax. | Derf, A., et al. 2019. Bioorg Chem. 85: 152-158. PMID: 30612081
- Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster. | Qin, F., et al. 2019. J Agric Food Chem. 67: 7266-7273. PMID: 31244199
- Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2. | Nam, S., et al. 2021. Antimicrob Agents Chemother. 65: e0013521. PMID: 33903104
- Enhanced flavour profiles through radicicol induced genomic variation in the lager yeasts, Saccharomyces pastorianus. | de la Cerda Garcia-Caro, R., et al. 2022. Yeast. 39: 535-547. PMID: 36127846
- Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor. | Yen, A., et al. 1994. Exp Cell Res. 214: 163-71. PMID: 7521842
- Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. | Oikawa, T., et al. 1993. Eur J Pharmacol. 241: 221-7. PMID: 7694864
- Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway. | Soga, S., et al. 1998. J Biol Chem. 273: 822-8. PMID: 9422737
Inhibitor of:
α4-crystallin, AHSA2, ATF-5, ATP-citrate synthase, BRP44, Cdc37, Cdc37L1, Cox, Cox-2, D630042P16Rik, DEME-6, DNAAF3, DnaJB12, DnaJC16, DnaJC18, DnaJC25, FKBP52, FLJ13236, GPAT2, GrpEL1, GrpEL2, GTPBP9, Helicobacter pylori HSP, HSBP1, HSBP1L1, HSFX1, HSP, HSP 105, HSP 56, HSP 60, HSP 65, HSP 78, HSP 90, HSPA12A, HSPA4L, HSPA6, HSPB7, HSPB9, HSPBAP1, HspBP1, I830012O16Rik, INO80C, Kar2, L7RN6, P23, PDH-E1α, PDH-E1β, Pin1l, prefoldin 1, prefoldin 2, prefoldin 3, PTGES3L, Rad51, RNA pol β, Sel-1L2, SGT1, SODD (BAG cochaperone 4), SSTK-IP, TCP-1 ε, TCP-1 η, TCP-1 γ, TCP-1 θ, TCP-1 ζ, TCP-1 ζ2, TFIIH p44, TID-1L, TPR, TTC17, UBE1Y1, UBL5, UIP5, UNC45A, UXT, Xlr3c, Xlr4c, Xlr5c, and Ydj1.Activator of:
AHA-1, BC015286, CCT B, CESK1, Cyp60, Derlin-2, DnaJA2, DnaJB14, DnaJB6, FKBP11, FKBP12.6, FKBPL, GP78-2, HSF2, HSFY2, HSP 40, HSP 47, HSP 56, HSP 75, HSP 78, HSP 90, HSP 90α, HSPA12B, HSPA1L, HSPA2, HSPB11, HSPB2, HSPC121, Npl4, Nup107, OIP106, RNF186, RPAP3, SGTB, STCH, STI1, TCP-1 β, TCP-1 δ, TCP-1 η, TCP-1 ζ, TEX264, TRAP1, Trap1a, UBE2J2, UBE2Q2, and UBPY.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Radicicol, 1 mg | sc-200620 | 1 mg | $92.00 | |||
Radicicol, 5 mg | sc-200620A | 5 mg | $333.00 |