SCYL3 Activators
SCYL3 Activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of SCYL3 through various signaling pathways. Forskolin, by increasing cAMP, activates PKA, which may lead to changes in phosphorylation patterns that enhance SCYL3 activity. PMA acts as a PKC activator, which can alter signaling cascades and potentially upregulate SCYL3's kinase function. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium, which can activate calcium-dependent kinases and phosphatases, potentially leading to an enhancement of SCYL3 activity. Epigallocatechin gallate, through its inhibition of kinases, and LY 294002, asa PI3K inhibitor, can modulate the cellular signaling environment to favor SCYL3's activity by reducing inhibitory phosphorylation events or shifting the balance towards pathways that engage SCYL3. U0126, by inhibiting MEK1/2, may relieve inhibitory control over SCYL3, indirectly increasing its activity, while SB 203580's inhibition of p38 MAPK could result in a similar elevation of SCYL3 function by altering the signaling milieu.
The biochemical landscape influencing SCYL3 is further shaped by compounds such as D-erythro-Sphingosine-1-phosphate, which activates G-protein coupled receptors leading to downstream signaling modifications that may enhance SCYL3's activity. Thapsigargin disrupts calcium homeostasis, potentially activating calcium-sensitive pathways that indirectly boost SCYL3 function. Moreover, Staurosporine, despite its broad-spectrum kinase inhibition, could preferentially relieve negative regulatory influences on SCYL3, leading to its activation. Genistein's inhibition of tyrosine kinases might also tilt signaling pathways in favor of SCYL3 activation by reducing competitive phosphorylation. Collectively, these activators influence various biochemical pathways and cellular processes to enhance the activity of SCYL3, demonstrating the complexity and interconnectivity of intracellular signaling networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activate PKA. PKA phosphorylation can influence various substrates and pathways that may enhance the activity of SCYL3 through indirect phosphorylation or by altering the cellular environment to favor SCYL3's kinase activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activated PKC can modulate the signaling pathways that indirectly increase the activity of SCYL3 by altering its phosphorylation state or changing interaction with its substrates. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular Ca2+ levels. Elevated Ca2+ can activate calcium-dependent kinases and phosphatases that may indirectly enhance the functional activity of SCYL3 by affecting its phosphorylation or conformational state. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that has been shown to inhibit a variety of kinases. By inhibiting competitive or regulatory kinases, EGCG may enhance the functional activity of SCYL3 by reducing inhibitory phosphorylation events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a PI3K inhibitor. By inhibiting PI3K, it reduces downstream Akt signaling which might be responsible for the phosphorylation and inactivation of proteins that are upstream activators or direct partners of SCYL3, thereby indirectly enhancing SCYL3 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate engages with G-protein coupled receptors to activate downstream signaling that can include kinase cascades potentially influencing the activity of SCYL3 by modifying its phosphorylation state or interaction with other proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to increased cytosolic calcium levels. This can activate calcium/calmodulin-dependent protein kinases or phosphatases, which may indirectly enhance SCYL3 activity through altered protein-protein interactions. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. By inhibiting kinases that negatively regulate SCYL3, staurosporine could relieve these inhibitory effects, leading to an indirect enhancement of SCYL3's activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor. Inhibition of p38 MAPK can alter the cellular signaling milieu in a way that indirectly upregulates or enhances the kinase activity of SCYL3 through changes in the phosphorylation landscape. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore, like ionomycin, and increases intracellular calcium levels. This may lead to the activation of calcium-sensitive signaling mechanisms that could indirectly enhance the functional activity of SCYL3. | ||||||