Scn4b Inhibitors
Scn4b inhibitors target the sodium channel subunit beta-4 (SCN4B), a protein that plays a crucial role in modulating the function of voltage-gated sodium channels (Nav) in excitable cells such as neurons and muscle fibers. SCN4B, which is encoded by the SCN4B gene, is one of the auxiliary subunits that modulates the kinetics and gating properties of the Nav1.4 channel, which is critical for the propagation of electrical signals. SCN4B contributes to the regulation of sodium channel density, fast and slow inactivation, and the overall excitability of cells. By influencing these aspects of sodium channel behavior, SCN4B impacts the amplitude and duration of action potentials, particularly in tissues that depend on rapid signal transduction, such as skeletal muscle and the central nervous system.
Inhibitors of SCN4B interfere with the normal modulatory functions of this subunit, which can result in altered sodium channel conductance and disrupted electrical signaling. These inhibitors may affect sodium influx by modifying the stability of the channel's open and inactivated states, potentially shifting the voltage-dependence of channel activation or inactivation. This could lead to changes in the excitability thresholds of neurons and muscle cells, influencing phenomena such as firing frequency and signal transmission fidelity. The inhibition of SCN4B can also impact protein-protein interactions at the channel complex, thereby affecting the integration of sodium channel activity with other signaling pathways. Understanding how SCN4B inhibitors alter these biophysical properties of sodium channels is essential for comprehending their role in modulating ion channel function in excitable tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may downregulate Scn4b expression by binding to its nuclear receptors, which could then repress the transcription of genes including Scn4b by recruiting co-repressors to the gene's promoter region. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
The active metabolite of Cholecalciferol could decrease Scn4b transcription by interacting with its receptor and altering the recruitment of DNA-binding proteins to the Scn4b promoter, thereby repressing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may diminish Scn4b gene transcription by inhibiting the activation of transcription factors that are necessary for Scn4b expression, through its antioxidant properties that modify the redox state of cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could attenuate Scn4b expression by activating sirtuins that deacetylate histones at the Scn4b gene promoter, leading to a more condensed chromatin state and reduced access for transcription machinery. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate might suppress Scn4b expression by inhibiting histone deacetylases, resulting in hyperacetylation of histones, which can lead to the silencing of gene transcription including the Scn4b gene. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could obstruct Scn4b expression by inhibiting DNA methyltransferases, leading to a decrease in methylation of the Scn4b promoter region and subsequent transcriptional repression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride may lead to a reduction in Scn4b expression through the inhibition of GSK-3 activity, altering the phosphorylation state of transcription factors that control Scn4b gene transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin could lead to the downregulation of Scn4b by elevating cAMP levels, which may activate protein kinase A (PKA) and subsequently inhibit transcription factor binding to the Scn4b promoter. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may repress Scn4b expression by activating the glucocorticoid receptor, which can translocate to the nucleus and interfere with transcription factor binding to the Scn4b promoter, leading to decreased gene expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid might inhibit Scn4b promoter activity by activating specific transcriptional repressors or by inducing the expression of microRNAs that target the Scn4b mRNA for degradation. | ||||||