Date published: 2026-4-13

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SCAP Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of SCAP monoclonal antibodies for studying Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP). SCAP monoclonal antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). SCAP plays a fundamental role in regulating lipid metabolism and cholesterol homeostasis by functioning as a cellular sterol level sensor. Through modulation of SREBP activity, SCAP influences the expression of genes responsible for lipid synthesis and uptake. Research focused on SCAP continues to reveal important insights about metabolic disorders and potential therapeutic approaches. Understanding SCAP's molecular mechanisms has significant implications for developing new treatments targeting lipid-related diseases. Investigating SCAP's role in cellular metabolism provides valuable knowledge about how cells maintain cholesterol balance. Scientists studying SCAP can uncover new regulatory pathways in lipid homeostasis. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing our understanding of cellular metabolism and human health.

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SCAP Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SCAP Antibody (9D5)

sc-13553mouse IgG2b κ540-707 (hamster)WB, IPhamster
17
(4)

SCAP CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SCAP CRISPR/Cas9 KO Plasmid (h)

sc-401474hGene KnockoutGFP0
(0)

SCAP HDR Plasmid (h)

sc-401474-HDRhHomology Directed RepairPuromycin0
(0)

SCAP Double Nickase Plasmid (h)

sc-401474-NIChGene KnockoutPuromycin0
(0)

SCAP Double Nickase Plasmid (h2)

sc-401474-NIC-2hGene KnockoutPuromycin0
(0)

SCAP CRISPR/Cas9 KO Plasmid (m2)

sc-433484-KO-2mGene KnockoutGFP0
(0)

SCAP HDR Plasmid (m2)

sc-433484-HDR-2mHomology Directed RepairPuromycin0
(0)

SCAP CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SCAP CRISPR Activation Plasmid (h)

sc-401474-ACThGene ActivationPuro, Blast, Hygro0
(0)

SCAP CRISPR Activation Plasmid (h2)

sc-401474-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SCAP siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SCAP siRNA (h)

sc-36462hGene SilencingN/A
2
(1)

SCAP shRNA Plasmid (h)

sc-36462-SHhGene SilencingPuromycin
2
(1)

SCAP shRNA (h) Lentiviral Particles

sc-36462-VhGene SilencingPuromycin
2
(1)

SCAP siRNA (m)

sc-36463mGene SilencingN/A
2
(0)

SCAP shRNA Plasmid (m)

sc-36463-SHmGene SilencingPuromycin
2
(0)

SCAP shRNA (m) Lentiviral Particles

sc-36463-VmGene SilencingPuromycin
2
(0)