SAS10 Activators
SAS10 activators encompass a range of compounds that influence various cellular signaling pathways, which indirectly affect the activity of SAS10. Compounds like Forskolin, Rolipram, and IBMX elevate intracellular cAMP levels, with Forskolin doing so by directly stimulating adenylate cyclase, while Rolipram and IBMX inhibit phosphodiesterase activities. The resulting increase in cAMP activates Protein Kinase A (PKA), which can phosphorylate substrates that interact with SAS10, consequently enhancing its activity. Similarly, compounds such as Epinephrine and Isoproterenol, which are adrenergic receptor agonists, and Glucagon, which acts through its own receptor, all ultimately raise cAMP levels and activate PKA, again influencing the functional activity of SAS10.
Other compounds like Caffeine and Histamine work through inhibition of phosphodiesterases and activation of H2 receptors, respectively, leading to increased cAMP levels and PKA activation. Prostaglandin E2 (PGE2) engages EP receptors, culminating in the same cAMP-dependent PKA activation pathway, potentially affecting SAS10 activity. Anisomycin and A23187 (Calcimycin), although through different mechanisms, activate MAPK pathways and increase intracellular calcium levels, respectively. Both pathways can lead to the activation of kinases that may phosphorylate proteins associated with SAS10, enhancing its activity. Ionomycin,like A23187, raises intracellular calcium levels and can activate calcium-dependent signaling cascades with the potential to modulate the activity of proteins that interact with SAS10, resulting in its functional activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA which can phosphorylate various substrates that may interact with SAS10, leading to its functional activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), thereby preventing the breakdown of cAMP. This results in increased cAMP levels which enhance PKA activity. PKA can phosphorylate proteins that may associate with SAS10, enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This can augment PKA and PKG activity, which may indirectly enhance the activation of SAS10 through phosphorylation of associated proteins. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, which can lead to the activation of adenylate cyclase and increased cAMP levels. Through cAMP-dependent signaling pathways, PKA is activated, which may enhance SAS10 activity indirectly. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a β-adrenergic agonist, also activates adenylate cyclase, raising cAMP levels and subsequently activating PKA. PKA then can phosphorylate substrates that could enhance the activity of SAS10. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels. Elevated cAMP activates PKA, which can lead to the phosphorylation of proteins that influence the activity of SAS10 in an enhancing manner. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H2 receptors, can increase intracellular cAMP levels, thereby activating PKA. PKA may phosphorylate substrates that could indirectly enhance SAS10 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to EP receptors, which can result in increased intracellular cAMP and activation of PKA. PKA can then phosphorylate proteins that are associated with SAS10, potentially enhancing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates MAPK pathways that can lead to the phosphorylation of a variety of substrates. These phosphorylation events can influence the activity of SAS10 indirectly by modifying proteins that interact with SAS10. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases, which may influence the phosphorylation status of proteins associated with SAS10, leading to its activation. | ||||||